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AFN941

 
National Institutes of Health

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2 relations

Broader (1)

Staurosporine
analogs & derivatives

Papers overview

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2017
2017
Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology.
The human epidermal growth factor receptor (EGFR) has been established as an attractive target for lung cancer therapy. However… Expand
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2013
2013
Improving EGFR kinase inhibitor design for the targeted treatment of lung cancer.
With over 174,000 new cases of lung cancer being diagnosed in the United States each year novel chemotherapy treatments with… Expand
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2007
2007
Anticancer drugs: Crystal-clear targets?
ABL http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?db=gene&c md=Retrieve&dopt=full_ report&list_uids=25 The identification of… Expand
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2007
2007
Therapy: Crystal-clear targets?
ABL http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?db=gene&c md=Retrieve&dopt=full_ report&list_uids=25 The identification of… Expand
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Highly Cited
2005
Highly Cited
2005
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.
Jak (Janus kinase) family nonreceptor tyrosine kinases are central mediators of cytokine signaling. The Jak kinases exhibit… Expand
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