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AF-2364

Known as: AF2364 
National Institutes of Health

Papers overview

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2011
2011
Adjudin disrupts spermatogenesis via the action of some unlikely partners
Adjudin, 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (formerly called AF-2364), is a potent analog of lonidamine [1-(2,4… 
2010
2010
AF-2364 is a prospective spermicide candidate.
AbstractInhibition of sperm motility has recently become a promising target for male contraceptive development. AF-2364, an… 
2008
2008
Adjudin targeting rabbit germ cell adhesion as a male contraceptive: a pharmacokinetics study.
Adjudin (1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide; formerly called AF-2364) has been shown to inhibit spermatogenesis… 
Highly Cited
2005
Highly Cited
2005
TGF-beta3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study.
Review
2005
Review
2005
AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data.
Highly Cited
2005
Highly Cited
2005
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis
Earlier studies in multiple epithelia have shown that cell–cell actin‐based adherens junction (AJ) dynamics are regulated, at… 
Highly Cited
2004
Highly Cited
2004
Interactions of Proteases, Protease Inhibitors, and the β1 Integrin/Laminin γ3 Protein Complex in the Regulation of Ectoplasmic Specialization Dynamics in the Rat Testis1
Abstract During spermatogenesis, developing germ cells migrate progressively across the seminiferous epithelium. This event… 
Highly Cited
2003
Highly Cited
2003
Sertoli-Germ Cell Adherens Junction Dynamics in the Testis Are Regulated by RhoB GTPase via the ROCK/LIMK Signaling Pathway1
Abstract During spermatogenesis, cell-cell actin-based adherens junctions (AJs), such as ectoplasmic specializations (ESs… 
Highly Cited
2003
Highly Cited
2003
Fer Kinase/FerT and Adherens Junction Dynamics in the Testis: An In Vitro and In Vivo Study1
Abstract Fer kinase is a 94-kDa cytoplasmic cell-cell actin-based adherens junction (AJ)-associated nonreceptor protein tyrosine… 
Highly Cited
2001
Highly Cited
2001
Two New Male Contraceptives Exert Their Effects by Depleting Germ Cells Prematurely from the Testis1
Abstract The three currently available male contraceptive approaches are 1) the barrier method such as the condom, 2) hormonal… 
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