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Identification of several proteins involved in regulation of sperm motility by proteomic analysis.
A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction
This study demonstrates for the first time that, prior to reaching the zona pellucida, sperm may release a surface protein that acts on the cumulus cells leading to the acrosome reaction, which may be important for determining the outcome of fertilization.
transient scrotal hyperthermia and levonorgestrel enhance testosterone-induced spermatogenesis suppression in men through increased germ cell apoptosis.
- Christina Wang, Y. Cui, R. Swerdloff
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 August 2007
Investigation of whether addition of heat exposure or a progestin to an androgen induces germ cell death and more complete and rapid spermatogenesis suppression found that TU plus heat resulted in low-sperm output that was maintained by continuous treatment with TU.
Predictive value of the area of expanded cumulus mass on development of porcine oocytes matured and fertilized in vitro.
PFF had an inhibiting effect on cumulus expansion, and the inhibitory effect decreased progressively with the increase in size of follicles from which PFF was obtained, andThe action of PFF on Cumulus expansion was affected by the PFF culture time.
Proteomic analysis of effect of hyperthermia on spermatogenesis in adult male mice.
A proteomic approach with two-dimensional gel electrophoresis analyses and mass spectroscopic identification of proteins with altered expression in mouse testes at different times after heat shock suggests numerous potential mechanisms for heat shock-induced spermatogenic disorder.
Effects of di-n-butyl phthalate on male rat reproduction following pubertal exposure.
It is concluded that high doses of DBP led to testicular toxicity, and low doses ofDBP led in the expression of proteins involved in spermatogenesis as well as changes in the number and function of Sertoli and Leydig cells, although no obvious morphological changes appeared.
The proteomic analysis of human neonatal umbilical cord serum by mass spectrometry
These data will contribute to a better understanding of the composition of umbilical cord serum and aid the discovery of novel biomarkers for the prenatal diagnosis of fetal abnormalities, including alpha-fetoprotein and periostin that were specific to newborn infants.
Gene functional research using polyethylenimine-mediated in vivo gene transfection into mouse spermatogenic cells.
PEI can efficiently mediate gene transfer into spermatocytes and might be useful for the functional research of sperMatogenic-cell specific genes such as the NYD-SP12 gene, which was visualized and was involved in the formation of acrosome during sPermatogenesis.
The protein profile of mouse mature cumulus-oocyte complex.
Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice.
It is demonstrated that Tex101 sperm were unable to pass through the UTJ of female genital tract, and several members of a disintegrin and metalloprotease (ADAM) transmembrane protein family with cell adhesion ability were lost in Tex101 knockout epididymal sperm.