All Fields
Computer Science
Medicine
FAQ
Contact
Sign in
ADX 47273
Known as:
ADX-47273
, ADX47273
Â
Â
Topic mentions per year
Topic mentions per year
2009-2018
0
1
2
3
2009
2018
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats.
Marta Marszalek-Grabska
,
Ewa Gibula-Bruzda
,
+7 authors
Jolanta Helena Kotlińska
Behavioural brain research
2018
Repeated exposure to and withdrawal from ethanol induces deficits in spatial reversal learning. Data indicate that metabotropic…Â
(More)
Is this relevant?
2011
2011
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
Jeffrey P Lamb
,
Darren W Engers
,
+4 authors
Craig W Lindsley
Bioorganic & medicinal chemistry letters
2011
This Letter describes a chemical lead optimization campaign directed at a weak mGlu(5) NAM discovered while developing SAR for…Â
(More)
Is this relevant?
2011
2011
Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP.
Katja Sabine Kroker
,
Georg Rast
,
Holger Rosenbrock
Neuropharmacology
2011
Conflicting findings are reported in the literature about the involvement of the mGlu5 receptor in hippocampal long-term…Â
(More)
Is this relevant?
Review
2011
Review
2011
Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
Shaun R. Stauffer
ACS chemical neuroscience
2011
This Review describes recent trends in the development of small molecule mGlu(5) positive allosteric modulators (PAMs). A large…Â
(More)
Is this relevant?
2010
2010
Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.
Holger Rosenbrock
,
Gert Jan Kramer
,
+5 authors
Ulrich H. Schroeder
European journal of pharmacology
2010
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a…Â
(More)
Is this relevant?
2009
2009
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273.
Darren W Engers
,
Alice L. Rodriguez
,
+6 authors
Craig W Lindsley
ChemMedChem
2009
An iterative analogue library synthesis strategy rapidly developed comprehensive SAR for the mGluR5 ago-potentiator ADX-47273…Â
(More)
Is this relevant?