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ADX 47273

Known as: ADX-47273, ADX47273 
 

Topic mentions per year

Topic mentions per year

2009-2018
012320092018

Papers overview

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2018
2018
ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats.
Repeated exposure to and withdrawal from ethanol induces deficits in spatial reversal learning. Data indicate that metabotropic… (More)
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2011
2011
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
This Letter describes a chemical lead optimization campaign directed at a weak mGlu(5) NAM discovered while developing SAR for… (More)
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2011
2011
Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP.
Conflicting findings are reported in the literature about the involvement of the mGlu5 receptor in hippocampal long-term… (More)
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Review
2011
Review
2011
Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
This Review describes recent trends in the development of small molecule mGlu(5) positive allosteric modulators (PAMs). A large… (More)
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2010
2010
Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a… (More)
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2009
2009
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273.
An iterative analogue library synthesis strategy rapidly developed comprehensive SAR for the mGluR5 ago-potentiator ADX-47273… (More)
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