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ADX 47273

Known as: ADX-47273, ADX47273 
National Institutes of Health

Papers overview

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2015
2015
Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism
RationaleImpaired N-methyl-d-aspartate (NMDA) receptor signalling underlies several psychiatric disorders that express high… 
2013
2013
Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.
Metabotropic glutamate receptor 5 (mGluR5) plays important roles in modulating neural activity and plasticity and has been… 
2012
2012
Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal…
Metabotropic glutamate-5 receptors (mGluR5), which physically and functionally interact with N-methyl-d-Aspartate (NMDA… 
2011
2011
Quantitative Analysis Reveals Multiple Mechanisms of Allosteric Modulation of the mGlu5 Receptor in Rat Astroglia
Positive and negative allosteric modulators (PAMs and NAMs, respectively) of the type 5 metabotropic glutamate (mGlu5) receptor… 
Highly Cited
2010
Highly Cited
2010
Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia
Highly Cited
2010
Highly Cited
2010
Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.
Highly Cited
2009
Highly Cited
2009
Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity.
Highly Cited
2008
Highly Cited
2008
ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with…
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) enhance N-methyl-d-aspartate receptor… 
2005
2005
Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1).
Adrenodoxin (Adx), a [2Fe-2S] vertebrate-type ferredoxin, transfers electrons from the NADPH-dependent flavoprotein Adx reductase… 
Highly Cited
2001
Highly Cited
2001
Androgens Alter Corticotropin Releasing Hormone and Arginine Vasopressin mRNA Within Forebrain Sites Known to Regulate Activity in the Hypothalamic‐Pituitary‐Adrenal Axis
To reveal direct effects of androgens, independent of glucocorticoids, we studied the effects of gonadectomy (GDX) in… 
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