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ADX 47273

Known as: ADX-47273, ADX47273 
 
National Institutes of Health

Papers overview

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2015
2015
RationaleImpaired N-methyl-d-aspartate (NMDA) receptor signalling underlies several psychiatric disorders that express high… Expand
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2013
2013
Metabotropic glutamate receptor 5 (mGluR5) plays important roles in modulating neural activity and plasticity and has been… Expand
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2012
2012
Metabotropic glutamate-5 receptors (mGluR5), which physically and functionally interact with N-methyl-d-Aspartate (NMDA… Expand
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2011
2011
Positive and negative allosteric modulators (PAMs and NAMs, respectively) of the type 5 metabotropic glutamate (mGlu5) receptor… Expand
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2011
2011
This Letter describes a chemical lead optimization campaign directed at a weak mGlu(5) NAM discovered while developing SAR for… Expand
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2010
2010
Metabotropic glutamate receptors of the subtype 5 (mGluR(5)) are located in brain regions implicated in schizophrenia such as the… Expand
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2009
2009
Recently, it has been proposed that activation of either metabotropic glutamate receptors e.g. mGlu(5) by positive allosteric… Expand
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Highly Cited
2008
Highly Cited
2008
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) enhance N-methyl-d-aspartate receptor… Expand
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Highly Cited
2001
Highly Cited
2001
To reveal direct effects of androgens, independent of glucocorticoids, we studied the effects of gonadectomy (GDX) in… Expand
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