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ADX 47273

Known as: ADX-47273, ADX47273 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
[Plasma relative abundance of epidermal growth factor receptor mutations predicts clinical response to epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced lung…
Objective: To determine whether relative abundance of epidermal growth factor receptor (EGFR) mutations in plasma predicts… 
2014
2014
Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake…
Evidence is emerging that positive and negative modulation of the metabotropic glutamate (mGluR5) receptors has the potential for… 
Review
2011
Review
2011
Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
This Review describes recent trends in the development of small molecule mGlu(5) positive allosteric modulators (PAMs). A large… 
2011
2011
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
2005
2005
Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1).
Adrenodoxin (Adx), a [2Fe-2S] vertebrate-type ferredoxin, transfers electrons from the NADPH-dependent flavoprotein Adx reductase… 
2003
2003
A conserved histidine in vertebrate-type ferredoxins is critical for redox-dependent dynamics.
Adrenodoxin (Adx) belongs to the family of Cys(4)Fe(2)S(2) vertebrate-type ferredoxins that shuttle electrons from NAD(P)H… 
2003
2003
Formation and functioning of fused cholesterol side-chain cleavage enzymes.
We studied the properties of various fused combinations of the components of the mitochondrial cholesterol side-chain cleavage… 
2002
2002
Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth.
Studies were performed to test the hypothesis that the absence of adrenal glucocorticoids late in gestation alters sympathetic… 
1991
1991
Effects of withdrawal of glucocorticoids on improving the function and enzymatic activities of liver mitochondria in female diabetic rats.
In the present work the effects of corticosterone restitution were examined in female rats with chronic streptozotocin (SZ… 
1987
1987
Effects of potassium bicarbonate on distal nephron Na−K-ATPase in adrenalectomized rabbits
Na−K-ATPase activity in the connecting tubule (CNT) and cortical collecting duct (CCD) has been shown to be influenced by KCl… 
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