FAQ

ADCY9 protein, human

Known as: EC 4.6.1.1, ADCY9, Type IX ATP Pyrophosphate-Lyase 
Adenylate cyclase type 9 (1353 aa, ~151 kDa) is encoded by the human ADCY9 gene. This protein is involved in the synthesis of cyclic AMP in response… (More)

Topic mentions per year

Topic mentions per year

1974-2018
051019742018

Related topics

Related topics

11 relations
ADCY9 geneAdenylyl Cyclase 9Enzyme GeneHomo sapiens
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Broader (1)

adenylate cyclase 9

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ADCY9 protein, human
Plasma membrane
Signal Transduction
Homo sapiens
Vascular Smooth Muscle Contraction Pathway
Adenylyl Cyclase 9

Papers overview

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Highly Cited
2009
Highly Cited
2009
miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA.
Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates diverse cellular functions. It has been found that CD4(+)CD25… (More)
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Highly Cited
1995
Highly Cited
1995
Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.
The murine Ca(2+)-stimulated adenylyl cyclase (type I) (EC 4.6.1.1), which is expressed predominantly in brain, was inactivated… (More)
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Highly Cited
1982
Highly Cited
1982
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
Anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins… (More)
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Highly Cited
1982
Highly Cited
1982
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
GTP and isoproterenol activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in washed membranes… (More)
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Highly Cited
1981
Highly Cited
1981
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
The diterpene, forskolin [half-maximal effective concentration (EC50), 5-10 microM] activates adenylate cyclase [ATP… (More)
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Highly Cited
1980
Highly Cited
1980
Subclasses of external adenosine receptors.
Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase… (More)
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1980
1980
Purification of the regulatory component of adenylate cyclase.
The regulatory component (G/F) of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] from rabbit liver plasma… (More)
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Highly Cited
1978
Highly Cited
1978
Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.
Treatment of pigeon erythrocyte membranes with cholera toxin and NAD(+) enhanced the GTP stimulation and suppressed the F… (More)
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Highly Cited
1977
Highly Cited
1977
Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site.
Treatment of turkey erthrocyte membranes with cholera toxin caused an enhancement of the basal and catecholamine-stimulated… (More)
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Highly Cited
1975
Highly Cited
1975
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the… (More)
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