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Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
TLDR
High usage of ITNs can dramatically alter African vector populations so that intense, predominantly indoor transmission is replaced by greatly lowered residual transmission, a greater proportion of which occurs outdoors. Expand
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
TLDR
How control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed are drawn together to show how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir. Expand
Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
TLDR
In Tanzania, malaria is commonly overdiagnosed in people presenting with severe febrile illness, especially in those living in areas with low to moderate transmission and in adults, with a failure to treat alternative causes of severe infection. Expand
Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies
TLDR
Interventions using current tools can result in major reductions in P. falciparum malaria transmission and the associated disease burden in Africa, although considerable reductions in prevalence can be achieved with existing tools and realistic coverage levels. Expand
Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure.
TLDR
This work compared the prevalence of IgG antibodies with three Plasmodium falciparum asexual stage antigens in individuals of all ages living at varying altitudes encompassing a range of transmission intensities from hyper- to hypoendemic in northeastern Tanzania, with alternative measures of transmission intensity. Expand
Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial
TLDR
Use of rapid diagnostic tests for malaria with routine microscopy, with basic training for clinical staff, did not in itself lead to any reduction in over-treatment for malaria. Expand
Antifolate antimalarial resistance in southeast Africa: a population-based analysis
TLDR
The findings emphasise that gene flow rather than new mutations has been the most common originator of resistance in African countries. Expand
Factors determining the occurrence of submicroscopic malaria infections and their relevance for control
TLDR
It is shown that submicroscopic parasite carriage is common in adults, in low-endemic settings and in chronic infections, and challenge the idea that individuals with little previous malaria exposure have insufficient immunity to control parasitaemia and suggest a role for molecular screening. Expand
Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis.
TLDR
A systematic review of endemic population surveys in which P. falciparum prevalence had been measured by both microscopy and a more-sensitive polymerase chain reaction (PCR)-based technique found that microscopy can miss a substantial proportion of P. Falconerum infections in surveys of endemic populations, especially in areas with low transmission of infection. Expand
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
TLDR
The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants. Expand
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