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ADAMTS3 gene

Known as: ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3, ADAMTS-4 
National Institutes of Health

Papers overview

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2017
2017
A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation
2014
2014
Nitric oxide inhibits autophagy via suppression of JNK in meniscal cells.
OBJECTIVE Autophagy is a potential protective mechanism that is involved in several degenerative diseases. Nitric oxide (NO) is… 
2014
2014
Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.
CONTEXT The ability of intermediate trophoblasts to invade maternal tissue during placentation depends on how well they can… 
2011
2011
Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.
Aggrecanases, particularly aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5), are believed to be key enzymes involved in the… 
2010
2010
Design, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4‐c]quinolin‐1‐one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors
A small set of aggrecanase inhibitors based on the pyrrolo[3,4‐c]quinolin‐1‐one or oxoisoindoline frameworks bearing a 4… 
Review
2008
Review
2008
Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.
Loss of aggrecan from articular cartilage is an early and critical event in the pathogenesis of osteoarthritis (OA) and is… 
2007
2007
Substrate Conformation Modulates Aggrecanase (ADAMTS-4) Affinity and Sequence Specificity
Protease-substrate interactions are governed by a variety of structural features. Although the substrate sequence specificities… 
2007
2007
Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system.
OBJECTIVE The major proteases responsible for aggrecan turnover in articular cartilage are the aggrecanases (ADAMTS-4 and ADAMTS… 
2006
2006
Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.
Review
2003
Review
2003
Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity.
Degradation of the cartilage proteoglycan, aggrecan, is an essential aspect of normal growth and development, and of joint… 
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