ADAMTS13 wt Allele

Known as: ADAMTS-13, DKFZp434C2322, A Disintegrin-Like and Metalloprotease With Thrombospondin Type 1 Motif, 13 Gene 
Human ADAMTS13 wild-type allele is located in the vicinity of 9q34 and is approximately 45 kb in length. This allele, which encodes a disintegrin and… (More)
National Institutes of Health

Related topics

Related topics

5 relations
9q34Blood coagulationHydrolysisIntegrin Binding
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease.
Vascular occlusion, thromboembolism and strokes are hallmark events in sickle cell disease (SCD). The von Willebrand factor (VWF… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack
BACKGROUND A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13) may influence von… (More)
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2008
2008
Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS-13).
BACKGROUND Over the last 4 years ADAMTS-13 measurement underwent dramatic progress with newer and simpler methods. AIMS Blind… (More)
Is this relevant?
2008
2008
Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura.
BACKGROUND Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von Willebrand… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13.
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder and plasma exchange (PEX) remains the primary treatment… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure.
OBJECTIVE The inability to regulate the inflammatory response initiated upon infection leads to severe sepsis, characterized by… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Human endothelial cells synthesize and release ADAMTS-13.
Hepatic stellate cells have been considered to be a primary source for human plasma ADAMTS-13, the von Willebrand factor (VWF… (More)
Is this relevant?
2005
2005
The course of ADAMTS-13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine.
The therapeutic efficacy of plasma exchange (PE) in thrombotic thrombocytopenic purpura (TTP) is attributed to the restoration in… (More)
  • table I
  • figure 1
  • figure 3
  • figure 2
Is this relevant?
2004
2004
von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura.
The congenital or acquired deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS-13 has been specifically… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Nonneutralizing IgM and IgG antibodies to von Willebrand factor-cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura.
Acquired thrombotic thrombocytopenic purpura (TTP) has been linked to severe deficiency of ADAMTS-13 activity caused by… (More)
Is this relevant?