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ADAMTS13 wt Allele

Known as: ADAMTS-13, DKFZp434C2322, A Disintegrin-Like and Metalloprotease With Thrombospondin Type 1 Motif, 13 Gene 
Human ADAMTS13 wild-type allele is located in the vicinity of 9q34 and is approximately 45 kb in length. This allele, which encodes a disintegrin and… 
National Institutes of Health

Related topics

Related topics

5 relations
9q34Blood coagulationHydrolysisIntegrin Binding
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Papers overview

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Highly Cited
2017
Highly Cited
2017
Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura.
Safety, tolerability, and pharmacokinetics of recombinant ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin… 
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Highly Cited
2012
Highly Cited
2012
Severe Dengue Is Associated with Consumption of von Willebrand Factor and Its Cleaving Enzyme ADAMTS-13
Background Thrombocytopenia, bleeding and plasma leakage are cardinal features of severe dengue. Endothelial cell activation with… 
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Highly Cited
2008
Highly Cited
2008
Prevalence of the ADAMTS‐13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura
Summary.  Background: Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von… 
Highly Cited
2007
Highly Cited
2007
Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS‐13
Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder and plasma exchange (PEX) remains the primary treatment… 
Highly Cited
2007
Highly Cited
2007
Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure*
Objective:The inability to regulate the inflammatory response initiated upon infection leads to severe sepsis, characterized by… 
Highly Cited
2006
Highly Cited
2006
Human endothelial cells synthesize and release ADAMTS‐13
Summary.  Hepatic stellate cells have been considered to be a primary source for human plasma ADAMTS‐13, the von Willebrand… 
Highly Cited
2006
Highly Cited
2006
A rapid test for the diagnosis of thrombotic thrombocytopenic purpura using surface enhanced laser desorption/ionization time‐of‐flight (SELDI‐TOF)‐mass spectrometry
Summary.  Background: Thrombotic thrombocytopenic purpura (TTP), a life‐threatening thrombotic microangiopathy, requires… 
Highly Cited
2004
Highly Cited
2004
von Willebrand factor cleaving protease (ADAMTS‐13) and ADAMTS‐13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura
The congenital or acquired deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS‐13 has been specifically… 
Highly Cited
2003
Highly Cited
2003
Nonneutralizing IgM and IgG antibodies to von Willebrand factor-cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura.
Acquired thrombotic thrombocytopenic purpura (TTP) has been linked to severe deficiency of ADAMTS-13 activity caused by… 
Highly Cited
2003
Highly Cited
2003
Measurement of von Willebrand factor‐cleaving protease (ADAMTS‐13) activity in plasma: a multicenter comparison of different assay methods
Summary.  A severely deficient ADAMTS‐13 activity (<5%) is a key laboratory finding confirming the diagnosis of thrombotic… 
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