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ACU-4429

National Institutes of Health

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emixustat

Papers overview

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2019
2019
Protective effect of RIPK1‐inhibitory compound in in vivo models for retinal degenerative disease
2015
2015
Bioanalysis of emixustat (ACU-4429) in whole blood collected with volumetric absorptive microsampling by LC-MS/MS.
BACKGROUND A method to quantify emixustat (an investigational drug agent) in human blood collected using volumetric absorptive… 
2015
2015
PHASE II, RANDOMIZED, PLACEBO-CONTROLLED, 90-DAY STUDY OF EMIXUSTAT HYDROCHLORIDE IN GEOGRAPHIC ATROPHY ASSOCIATED WITH DRY AGE-RELATED MACULAR DEGENERATION
Purpose: This study assessed the safety, tolerability, and pharmacodynamics of emixustat hydrochloride (ACU-4429), a novel visual… 
2013
2013
A Phase 2 Double-masked, Placebo-controlled, Dose Ranging Study of Emixustat Hydrochloride (ACU-4429) in Subjects with GA Associated with Dry AMD
Review
2013
Review
2013
Update on current and future novel therapies for dry age-related macular degeneration
Age-related macular degeneration (ARMD) is the leading cause of irreversible blindness in developed countries. There are… 
Highly Cited
2012
Highly Cited
2012
SAFETY AND EFFECT ON ROD FUNCTION OF ACU-4429, A NOVEL SMALL-MOLECULE VISUAL CYCLE MODULATOR
Background: ACU-4429 is a first in class small-molecule visual cycle modulator that inhibits the isomerase complex and, in mouse… 
2012
2012
Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy
2012
2012
A Phase I Dose-Ranging Study of ACU-4429, a Novel Visual Cycle Modulator, in Healthy Volunteers
Review
2010
Review
2010
FDA Pipeline preview, April 2010 (Miglustat, Insulin human inhalation powder, APF530, Exenatide LAR, Pirfenidone, ACU-4429, L-asparaginase, Alpha1-proteinase inhibitor, LIPO-102, QPI-1002/I5NP, MA09…
Recent FDA action (through March 2010) related to Miglustat, Insulin human inhalation powder, APF530, Exenatide LAR, Pirfenidone… 
2009
2009
Phase 1, Dose-Escalating Study of the Safety, Tolerability, and Pharmacokinetics of ACU-4429 in Healthy Volunteers
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