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ACT-132577

National Institutes of Health

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2 relations

Broader (2)

PyrimidinesSulfonamides

Papers overview

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2019
2019
Effect of Macitentan on the Pharmacokinetics of the Breast Cancer Resistance Protein Substrates, Rosuvastatin and Riociguat, in Healthy Male Subjects
Macitentan is a clinically approved endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH… 
2019
2019
Combination Therapy of Pulmonary Arterial Hypertension with Vardenafil and Macitentan Assessed in a Human Ex Vivo Model
PurposeTreatment of pulmonary arterial hypertension (PAH) by vasodilator drug monotherapy is often limited in its effectiveness… 
2018
2018
Target : Endothelin Receptor Pathway : GPCR / G Protein Solubility : 10 mM in DMSO Caution
  • 2018
  • Corpus ID: 50911802
BIOLOGICAL ACTIVITY: Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the… 
2017
2017
Pharmacokinetics of Macitentan in Patients With Pulmonary Arterial Hypertension and Comparison With Healthy Subjects
Macitentan is a worldwide approved dual endothelin receptor antagonist that has demonstrated efficacy in the treatment of… 
2015
2015
Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts
Objective. To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite… 
2015
2015
Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry.
It was reported that macitentan was metabolized predominantly by cytochrome P450 3A4, and ACT-132577, its pharmacologically… 
2012
2012
Lack of relevant pharmacokinetic interactions between the new dual endothelin receptor antagonist macitentan and sildenafil in healthy subjects
Macitentan, a new potent, dual endothelin receptor antagonist (ERA), is a potential treatment for pulmonary arterial hypertension… 
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