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ACAN gene

Known as: aggrecan proteoglycan, ACAN, AGGRECAN 
National Institutes of Health

Papers overview

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2013
2013
Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System
Intervertebral disc (IVD) cell therapy with unconditioned 2D expanded mesenchymal stem cells (MSC) is a promising concept yet… 
Highly Cited
2004
Highly Cited
2004
Influence of medium composition, static and stirred conditions on the proliferation of and matrix protein expression of bovine articular chondrocytes cultured in a 3-D collagen scaffold.
2004
2004
Identification of Novel Human Aggrecan T Cell Epitopes in HLA-B27 Transgenic Mice Associated with Spondyloarthropathy1
The pathology of ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies (SpA) is closely associated with the… 
Highly Cited
2003
Highly Cited
2003
Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies.
OBJECTIVE Experimental immunity to the G1 domain of the cartilage proteoglycan (PG) aggrecan (AG1) leads to the development of… 
2002
2002
Perlecan, the multidomain HS-proteoglycan of basement membranes, is a prominent pericellular component of ovine hypertrophic vertebral growth plate and cartilaginous endplate chondrocytes
Abstract. The aim of this study was to immunolocalise perlecan in ovine vertebral growth plate (VGP) and cartilaginous endplate… 
2001
2001
Time-dependent aggrecan gene expression of articular chondrocytes in response to hyperosmotic loading.
OBJECTIVE To investigate the effects of increasing extracellular osmolality on aggrecan gene expression and cell size in cultured… 
Highly Cited
1994
Highly Cited
1994
Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.
Highly Cited
1994
Highly Cited
1994
Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan.
We have isolated and sequenced overlapping cDNA clones encoding the entire core protein of aggrecan (the large aggregating… 
1994
1994
The structure of the rat aggrecan gene and preliminary characterization of its promoter.
Highly Cited
1993
Highly Cited
1993
Assignment of the human aggrecan gene (AGC1) to 15q26 using fluorescence in situ hybridization analysis.
The large aggregating proteoglycan aggrecan is a major structural component of the extracellular matrix of articular cartilage… 
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