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Animals lacking link protein have attenuated perineuronal nets and persistent plasticity.
- D. Carulli, T. Pizzorusso, +7 authors J. Fawcett
- Biology, Medicine
- Brain : a journal of neurology
- 1 August 2010
Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. However the… Expand
Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice
Mucification of the cumulus layer around the oocyte is an obligatory process for female fertility. Tumor necrosis factor-induced protein-6 (TNFIP6 or TSG6) has been shown to be specifically expressed… Expand
Macrophage/particle interactions: effect of size, composition and surface area.
- A. Shanbhag, J. Jacobs, J. Black, J. Galante, T. Glant
- Materials Science, Medicine
- Journal of biomedical materials research
Particulate wear-debris are detected in histiocytes/macrophages of granulomatous tissues adjacent to loose joint prostheses. Such cell-particle interactions have been simulated in vitro by… Expand
Cutting Edge: Cbl-b: One of the Key Molecules Tuning CD28- and CTLA-4-Mediated T Cell Costimulation1
Cbl-b negatively regulates CD28-dependent T cell activation. In this report, we tested the hypothesis that CD28 and CTLA-4 have opposite roles in tuning T cell activation threshold by controlling the… Expand
Composition and morphology of wear debris in failed uncemented total hip replacement.
- A. Shanbhag, J. Jacobs, T. Glant, J. Gilbert, J. Black, J. Galante
- The Journal of bone and joint surgery. British…
Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip replacements were examined. Particles in the membranes were characterised by electron microscopy,… Expand
Osteolysis: basic science.
- J. Jacobs, K. Roebuck, M. Archibeck, N. Hallab, T. Glant
- Clinical orthopaedics and related research
- 1 December 2001
Since the recognition of aseptic loosening by Charnley in the early 1960s, much information has been gained on the basic science of periprosthetic bone loss. Initially termed cement disease, it now… Expand
Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.
OBJECTIVE To identify characteristic changes in large aggregating (aggrecan) and small proteoglycan (PG) populations in articular cartilages during osteoarthritis (OA) and rheumatoid arthritis (RA).… Expand
Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.
Immunization with chondroitinase ABC-digested fetal human cartilage proteoglycan and Freund's complete adjuvant induced polyarthritis and ankylosing spondylitis in female BALB/c mice. The initial… Expand
The Effects of Particulate Wear Debris, Cytokines, and Growth Factors on the Functions of MG-63 Osteoblasts
- C. Vermes, R. Chandrasekaran, J. Jacobs, J. Galante, K. Roebuck, T. Glant
- The Journal of bone and joint surgery. American…
- 1 February 2001
Background: Particle-challenged cells release cytokines, chemokines, and eicosanoids, which contribute to periprosthetic osteolysis. The particle-induced activation of macrophages and monocytes has… Expand
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis
- Charles D. Kaplan, J. Valdez, +4 authors A. Finnegan
- Biology, Medicine
- Arthritis research
- 2 October 2001
BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype… Expand