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ABT 888

Known as: ABT-888, ABT888, PARP-1 inhibitor ABT-888 
A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Purpose: Little is known about the optimal clinical use of ABT-888 (veliparib) for treatment of glioblastoma. ABT-888 is a PARP… Expand
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Highly Cited
2014
Highly Cited
2014
SummaryAndrogen receptor-mediated transcription is directly coupled with the induction of DNA damage, and castration-resistant… Expand
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Highly Cited
2012
Highly Cited
2012
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA… Expand
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Highly Cited
2012
Highly Cited
2012
Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical trials as cancer therapeutics, yet the… Expand
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Highly Cited
2011
Highly Cited
2011
A phase I trial of ABT-888 (veliparib), a PARP inhibitor, in combination with topotecan, a topoisomerase I-targeted agent, was… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE We conducted the first phase 0 clinical trial in oncology of a therapeutic agent under the Exploratory Investigational… Expand
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Highly Cited
2009
Highly Cited
2009
We have developed a series of cyclic amine-containing benzimidazole carboxamide PARP inhibitors with a methyl-substituted… Expand
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Highly Cited
2009
Highly Cited
2009
Many established cancer therapies involve DNA-damaging chemotherapy or radiotherapy. Gain of DNA repair capacity of the tumor… Expand
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Highly Cited
2008
Highly Cited
2008
Poly(ADP-ribose) polymerase (PARP) senses DNA breaks and facilitates DNA repair via the polyADP-ribosylation of various DNA… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel orally bioavailable poly(ADP-ribose… Expand
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