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ABT 594

Known as: ABT-594 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Population pharmacokinetics of ABT‐594 in subjects with diabetic peripheral neuropathic pain
What is known and Objective: ABT‐594 is a non‐opioid, non‐NSAID analgesic. The objective of this work was to characterize the… 
2006
2006
Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting drug-induced emesis
2006
2006
Preclinical Pharmacology of ABT-594: A Nicotinic Acetylcholine Receptor Agonist for the Treatment of Pain
ABT-594 [(R)-5-(2-azetedinylmethoxy)-2-chloropyridine mono-tosylate salt] is a neuronal nicotinic acetylcholine receptor (nAChR… 
2006
2006
Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.
A series of highly sterically hindered secondary amine analogues of pyridylmethylamine (7a-f, 8a-c) and positional isomeric… 
2003
2003
Thermodynamic conformational analysis and structural stability of the nicotinic analgesic ABT-594
This work presents a theoretical study of the nicotinic analgesic ABT-594. We describe its neutral (precursor) and protonated… 
Review
2001
Review
2001
The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control
Due to the limitations of currently available analgesics, a number of novel alternatives are currently under investigation… 
2000
2000
The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.
1999
1999
The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions.
The present experiments were designed to extend previous work showing that acute intermittent (-)nicotine treatment upregulates… 
Review
1998
Review
1998
The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594
1998
1998
ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain
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