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ABT 538

Known as: ABT-538, ABT538 
 
National Institutes of Health

Papers overview

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2011
2011
To understand the underlying mechanisms of significant differences in dissociation rate constant among different inhibitors for… Expand
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2002
2002
Kinetic characterization and cross resistance pattern studies of HIV-1 aspartic protase (PR) inhibitors have shown that some… Expand
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1998
1998
Recent experimental findings with HIV-1 protease (HIV-1 PR) mutants containing variations at four residues, M46I, L63P, V82T and… Expand
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Highly Cited
1997
Highly Cited
1997
The metabolism and disposition of [14C]ritonavir (ABT-538, NOR-VIR), a potent, orally active HIV-1 protease inhibitor, were… Expand
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Highly Cited
1996
Highly Cited
1996
The HIV-1 protease inhibitor ritonavir (ABT-538) undergoes cytochrome P450-mediated biotransformation in human liver microsomes… Expand
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1996
1996
OBJECTIVE To define genotypic and phenotypic resistance patterns following prolonged therapy with the protease inhibitor… Expand
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Highly Cited
1996
Highly Cited
1996
Mutations in the human immunodeficiency virus (HIV) protease (L90M, G48V, and L90M/G48V) arise when HIV is passaged in the… Expand
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Highly Cited
1995
Highly Cited
1995
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes… Expand
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Highly Cited
1995
Highly Cited
1995
Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of… Expand
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Highly Cited
1995
Highly Cited
1995
Inhibitors of the human immunodeficiency virus protease represent a promising new class of antiretroviral drugs for the treatment… Expand
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