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ABT 538

Known as: ABT-538, ABT538 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Ritonavir

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Strength of Hydrogen Bond Network Takes Crucial Roles in the Dissociation Process of Inhibitors from the HIV-1 Protease Binding Pocket
To understand the underlying mechanisms of significant differences in dissociation rate constant among different inhibitors for… 
2002
2002
Computational studies of the resistance patterns of mutant HIV-1 aspartic proteases towards ABT-538 (ritonavir) and design of new derivatives.
2001
2001
A peptide inhibitor of HIV-1 protease using alpha, beta- dehydro residues: a structure based computer model.
HIV-1 encodes an aspartic protease, an enzyme crucial to viral maturation and infectivity. It is responsible for the cleavage of… 
2000
2000
Identifying and Characterizing HIV Protease Inhibitors.
HIV protease catalyzes the hydrolysis of specific peptide bonds of viral polyproteins, thus processing these polyproteins into… 
1998
1998
A computational study of the resistance of HIV-1 aspartic protease to the inhibitors ABT-538 and VX-478 and design of new analogues.
Recent experimental findings with HIV-1 protease (HIV-1 PR) mutants containing variations at four residues, M46I, L63P, V82T and… 
1997
1997
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.
1995
1995
Random copolymers containing specific ratios of negatively charged and aromatic amino acids bind V3 disulfide loop and neutralize diverse HIV type 1 isolates.
Random copolymers of polyamino acids containing negatively charged and aromatic residues at specific ratios appear to bind HIV… 
1995
1995
Update on HIV protease inhibitors.
When HIV replicates, it forms large precursor proteins that are cleaved and processed by HIV protease to generate smaller viral… 
1995
1995
[Which is the strategy? The latest in the use of antiretrovirals].
The four main antiretroviral drugs, or nucleoside analogs, used in AIDS treatment are AZT, ddI, ddC and d4T. AZT is generally… 
1995
1995
ABT-538 increases CD4 counts.
ABT-538, a new protease inhibitor, appears to increase CD4 counts and viral load in HIV-infected persons. In a four-week placebo… 
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