• Publications
  • Influence
Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda.
The C terminus of transcription factor NusA from Escherichia coli comprises two repeat units, which bind during antitermination to protein N from phage lambda. To delineate the structural basis ofExpand
  • 26
  • 4
  • PDF
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase.
The soil bacterium Pseudomonas putida 86 uses quinoline as a sole source of carbon and energy. Quinoline 2-oxidoreductase (Qor) catalyzes the first metabolic step converting quinoline toExpand
  • 62
  • 3
Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding.
NusB is a prokaryotic transcription factor involved in antitermination processes, during which it interacts with the boxA portion of the mRNA nut site. Previous studies have shown that NusB exhibitsExpand
  • 9
  • 2
  • PDF
Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors.
[structure] Two water-soluble fullerene derivatives have been computer-designed and synthesized. They may exhibit interesting anti-HIV activity owing to the presence of two ammonium groupsExpand
  • 82
  • 1
  • PDF
Aspartic protease inhibitors. An integrated approach for the design andsynthesis of diaminodiol-based peptidomimetics.
Aspartic proteases play key roles in a variety of pathologies, including acquired immunodeficiency syndrome. Peptidomimetic inhibitors can act as drugs to combat these pathologies. We have developedExpand
  • 9
  • 1
Aspartic protease inhibitors
Aspartic proteases play key roles in a variety of pathologies, including acquired immunodeficiency syndrome. Peptidomimetic inhibitors can act as drugs to combat these pathologies. We have developedExpand
  • 28
Computational studies of the resistance patterns of mutant HIV-1 aspartic proteases towards ABT-538 (ritonavir) and design of new derivatives.
Kinetic characterization and cross resistance pattern studies of HIV-1 aspartic protase (PR) inhibitors have shown that some mutations cause considerable reduction in inhibition efficiency. We haveExpand
  • 13
Computational design of new cyclic urea inhibitors for improved binding of HIV-1 aspartic protease.
We report in this paper the design, by means of computational techniques, of new cyclic urea inhibitors of the HIV aspartic protease. The relationship between the complexation energies of the enzymeExpand
  • 4
Structural Analysis of Quinoline 2-Oxidoreductase from Pseudomonas putida 86
The crystal structure of the Quinoline 2-Oxidoreductase (Qor), a member of the molybdenum hydroxylase family, was solved at 1.8 A resolution. Still controversial for molybdenum hydroxylases is theExpand