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ABT 239

Known as: ABT-239, ABT239 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease
Highly Cited
2010
Highly Cited
2010
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats
Highly Cited
2010
Highly Cited
2010
Effects of the Cognition-Enhancing Agent ABT-239 on Fetal Ethanol-Induced Deficits in Dentate Gyrus Synaptic Plasticity
Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically… 
Highly Cited
2010
Highly Cited
2010
Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.
BACKGROUND Drinking during pregnancy has been associated with learning disabilities in affected offspring. At present, there are… 
2009
2009
Use of the H3 receptor antagonist radioligand [3H]‐A‐349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists
Background and purpose:  The histamine H3 receptor antagonist radioligand [3H]‐A‐349821 was characterized as a radiotracer for… 
Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and…
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is… 
Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties
Histamine H3 receptor antagonists are being developed to treat a variety of neurological and cognitive disorders that may be… 
Highly Cited
2005
Highly Cited
2005
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs
Highly Cited
2005
Highly Cited
2005
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and… 
Highly Cited
2005
Highly Cited
2005
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.
A new series of H3 receptor antagonists was discovered with nanomolar and subnanomolar affinities at human and rat H3 receptors… 
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