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ABT 239
Known as:
ABT-239
, ABT239
National Institutes of Health
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Highly Cited
2011
Highly Cited
2011
In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease
R. Bitner
,
S. Markosyan
,
A. Nikkel
,
J. Brioni
Neuropharmacology
2011
Corpus ID: 12812005
Highly Cited
2010
Highly Cited
2010
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats
G. Hsieh
,
P. Chandran
,
+14 authors
P. Honore
Pharmacology, Biochemistry and Behavior
2010
Corpus ID: 25876851
Highly Cited
2010
Highly Cited
2010
Effects of the Cognition-Enhancing Agent ABT-239 on Fetal Ethanol-Induced Deficits in Dentate Gyrus Synaptic Plasticity
R. K. Varaschin
,
K. Akers
,
Martina J. Rosenberg
,
D. Hamilton
,
D. Savage
Journal of Pharmacology and Experimental…
2010
Corpus ID: 23360931
Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically…
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Highly Cited
2010
Highly Cited
2010
Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.
D. Savage
,
Martina J. Rosenberg
,
+8 authors
D. Hamilton
Alcoholism: Clinical and Experimental Research
2010
Corpus ID: 33306875
BACKGROUND Drinking during pregnancy has been associated with learning disabilities in affected offspring. At present, there are…
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2009
2009
Use of the H3 receptor antagonist radioligand [3H]‐A‐349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists
T. Miller
,
I. Milicic
,
+7 authors
T. Esbenshade
British Journal of Pharmacology
2009
Corpus ID: 37156002
Background and purpose: The histamine H3 receptor antagonist radioligand [3H]‐A‐349821 was characterized as a radiotracer for…
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Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and…
G. Fox
,
T. Esbenshade
,
+22 authors
A. Hancock
Journal of Pharmacology and Experimental…
2005
Corpus ID: 15430117
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is…
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Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties
T. Esbenshade
,
G. Fox
,
+12 authors
A. Hancock
Journal of Pharmacology and Experimental…
2005
Corpus ID: 573355
Histamine H3 receptor antagonists are being developed to treat a variety of neurological and cognitive disorders that may be…
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Highly Cited
2005
Highly Cited
2005
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs
Min Zhang
,
M. E. Ballard
,
L. Pan
,
S. Roberts
,
L. Rueter
Brain Research
2005
Corpus ID: 25997640
Highly Cited
2005
Highly Cited
2005
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
M. Cowart
,
R. Faghih
,
+9 authors
A. Hancock
Journal of Medicinal Chemistry
2005
Corpus ID: 7633641
H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and…
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Highly Cited
2005
Highly Cited
2005
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.
Minghua Sun
,
Chen Zhao
,
+9 authors
M. Cowart
Journal of Medicinal Chemistry
2005
Corpus ID: 24031466
A new series of H3 receptor antagonists was discovered with nanomolar and subnanomolar affinities at human and rat H3 receptors…
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