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ABT 239

Known as: ABT-239, ABT239 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive…
Histaminergic H3 receptors (H3R) antagonists enhance cognition in preclinical models and modulate neurotransmission, in… 
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2014
2014
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice
The multifaceted pathogenesis of temporal lobe epilepsy (TLE) offers a number of adjunctive therapeutic prospects. One such… 
Highly Cited
2010
Highly Cited
2010
Effects of the Cognition-Enhancing Agent ABT-239 on Fetal Ethanol-Induced Deficits in Dentate Gyrus Synaptic Plasticity
Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically… 
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Highly Cited
2010
Highly Cited
2010
Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.
BACKGROUND Drinking during pregnancy has been associated with learning disabilities in affected offspring. At present, there are… 
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2009
2009
Use of the H3 receptor antagonist radioligand [3H]‐A‐349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists
Background and purpose:  The histamine H3 receptor antagonist radioligand [3H]‐A‐349821 was characterized as a radiotracer for… 
Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and…
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is… 
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Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties
Histamine H3 receptor antagonists are being developed to treat a variety of neurological and cognitive disorders that may be… 
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Highly Cited
2005
Highly Cited
2005
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and… 
2005
2005
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs
Since H3 receptor (H3R) antagonists/inverse agonists can improve cognitive function in animal models, they may have the potential… 
Highly Cited
2005
Highly Cited
2005
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.
A new series of H3 receptor antagonists was discovered with nanomolar and subnanomolar affinities at human and rat H3 receptors… 
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