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ABT 239

Known as: ABT-239, ABT239 
 
National Institutes of Health

Papers overview

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2016
2016
Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive…
Histaminergic H3 receptors (H3R) antagonists enhance cognition in preclinical models and modulate neurotransmission, in… Expand
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2014
2014
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice
The multifaceted pathogenesis of temporal lobe epilepsy (TLE) offers a number of adjunctive therapeutic prospects. One such… Expand
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2013
2013
Selective brain region activation by histamine H3 receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression
Histamine axons originate solely from the tuberomamillary nucleus (TMN) to innervate almost all brain regions. This feature is… Expand
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Highly Cited
2011
Highly Cited
2011
In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease
Histamine H(3) receptor antagonists enhance cognition in preclinical models and have been proposed as novel therapeutics for… Expand
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Highly Cited
2010
Highly Cited
2010
Effects of the Cognition-Enhancing Agent ABT-239 on Fetal Ethanol-Induced Deficits in Dentate Gyrus Synaptic Plasticity
Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically… Expand
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Highly Cited
2010
Highly Cited
2010
Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.
BACKGROUND Drinking during pregnancy has been associated with learning disabilities in affected offspring. At present, there are… Expand
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Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and…
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is… Expand
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Highly Cited
2005
Highly Cited
2005
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H3 Receptor Antagonist with Drug-Like Properties
Histamine H3 receptor antagonists are being developed to treat a variety of neurological and cognitive disorders that may be… Expand
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Highly Cited
2005
Highly Cited
2005
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
H(3) receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and… Expand
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2005
2005
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs
Since H3 receptor (H3R) antagonists/inverse agonists can improve cognitive function in animal models, they may have the potential… Expand
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