ABT 239

Known as: ABT-239, ABT239 
 
National Institutes of Health

Papers overview

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2016
2016
Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H<ce:inf loc=post>3</ce:inf> receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert…
Histaminergic H3 receptors (H3R) antagonists enhance cognition in preclinical models and modulate neurotransmission, in… (More)
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2014
2014
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice
The multifaceted pathogenesis of temporal lobe epilepsy (TLE) offers a number of adjunctive therapeutic prospects. One such… (More)
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2013
2013
Selective brain region activation by histamine H<ce:inf loc=post>3</ce:inf> receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression
Histamine axons originate solely from the tuberomamillary nucleus (TMN) to innervate almost all brain regions. This feature is… (More)
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2012
2012
Effects of the histamine H₃ receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice.
BACKGROUND The strong correlation between central histaminergic and cholinergic pathways on cognitive processes has been reported… (More)
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2011
2011
In-vivo histamine H<ce:inf loc=post>3</ce:inf> receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease
Histamine H(3) receptor antagonists enhance cognition in preclinical models and have been proposed as novel therapeutics for… (More)
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2010
2010
Effects of the cognition-enhancing agent ABT-239 on fetal ethanol-induced deficits in dentate gyrus synaptic plasticity.
Prenatal ethanol exposure causes deficits in hippocampal synaptic plasticity and learning. At present, there are no clinically… (More)
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2010
2010
Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists
H3-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their… (More)
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2010
2010
H<ce:inf loc=post>4</ce:inf> receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats
The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine… (More)
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Highly Cited
2004
Highly Cited
2004
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and…
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is… (More)
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2004
2004
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties.
Histamine H3 receptor antagonists are being developed to treat a variety of neurological and cognitive disorders that may be… (More)
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