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ABCC6 gene

Known as: MLP1, MRP6, MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 6 
This gene is involved in the active transport of xenobiotics and glutathione conjugates into cells.
National Institutes of Health

Related topics

Related topics

9 relations
ABCC6 protein, humanHomo sapiensLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum–causing mutations in the ABCC6 transporter
Mutations in ABC subfamily C member 6 (ABCC6) transporter are associated with pseudoxanthoma elasticum (PXE), a disease resulting… 
2018
2018
New insights on the functional role of URG7 in the cellular response to ER stress
Up‐regulated Gene clone 7 (URG7) is an ER resident protein, whose expression is up‐regulated in the presence of hepatitis B virus… 
2013
2013
Analysis of Pseudoxanthoma Elasticum-Causing Missense Mutants of ABCC6 in vivo; Pharmacological Correction of the Mislocalized Proteins
Mutations in the ABCC6 gene cause soft tissue calcification in pseudoxanthoma elasticum (PXE) and in some patients generalized… 
2009
2009
Clustering of disease-causing mutations on the domain-domain interfaces of ABCC6.
2007
2007
The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin.
Hepatitis B x antigen (HBxAg) contributes significantly to the pathogenesis of chronic infection and development of… 
2005
2005
Patients with premature coronary artery disease who carry the ABCC6 R1141X mutation have no Pseudoxanthoma Elasticum phenotype.
2005
2005
New ABCC6 gene mutations in German pseudoxanthoma elasticum patients
Pseudoxanthoma elasticum (PXE; OMIM 177850 and 264800) is a rare heritable disorder of the connective tissue affecting the… 
Review
2005
Review
2005
Novel Mutations in the ABC6 Gene of German Patients with Pseudoxanthoma Elasticum
Pseudoxanthoma elasticum (PXE) is a heritable disorder of the connective tissue affecting the skin, eyes, and cardiovascular… 
2004
2004
Assessment of a rapid-cycle PCR assay for the identification of the recurrent c.3421C>T mutation in the ABCC6 gene in pseudoxanthoma elasticum patients
Pseudoxanthoma elasticum (PXE) is a heritable disorder of the connective tissue. Mutations in the ABCC6 gene could be linked to… 
2001
2001
Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1
Tetramethylrosamine (TMR) is excluded from P‐glycoprotein (MDR1)‐enriched cell lines, but it stains efficiently MDR1‐poor parent… 
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