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AAL 881

Known as: AAL-881, AAL881, NVP-AAL881-NX 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Isoquinolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model
Background and aimsActivation of the mitogen-activated protein kinase–extracellular-signal-regulated kinase (ERK) pathways plays… 
Review
2008
Review
2008
Current available therapies and future directions in the treatment of malignant gliomas
The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing… 
Highly Cited
2007
Highly Cited
2007
Targeting BRAFV600E in thyroid carcinoma: therapeutic implications
B-Raf is an important mediator of cell proliferation and survival signals transduced via the Ras-Raf-MEK-ERK cascade. BRAF… 
Highly Cited
2006
Highly Cited
2006
AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma.
Malignant gliomas are highly proliferative and angiogenic cancers resistant to conventional therapies. Although RAS and RAF… 
Highly Cited
2006
Highly Cited
2006
Inhibitors of Raf Kinase Activity Block Growth of Thyroid Cancer Cells with RET/PTC or BRAF Mutations In vitro and In vivo
Purpose: Papillary thyroid carcinomas are associated with nonoverlapping activating mutations of RET, NTRK, RAS and BRAF, which… 
Review
2006
Review
2006
Inhibitors of Raf KinaseActivity Block Growthof Thyroid Cancer Cells with RET / PTC or BRAF Mutations In vitro and In vivo
Purpose: Papillary thyroid carcinomas are associated with nonoverlapping activating mutations ofRET,NTRK,RAS andBRAF… 
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