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A-582941

National Institutes of Health

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PyridazinesPyrroles

Papers overview

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2017
2017
Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex
2015
2015
Pro‐cognitive activity in rats of 3‐furan‐2‐yl‐N‐p‐tolyl‐acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor
α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is… 
2012
2012
Type I and II positive allosteric modulators differentially modulate agonist‐induced up‐regulation of α7 nicotinic acetylcholine receptors
Long‐term treatment with nicotine or selective α7 nicotinic acetylcholine receptor (nAChR) agonists increases the number of α7… 
2011
2011
Functional characterization and high-throughput screening of positive allosteric modulators of α7 nicotinic acetylcholine receptors in IMR-32 neuroblastoma cells.
α7 nicotinic acetylcholine receptors (nAChRs) are characterized by relatively low ACh sensitivity, rapid activation, and fast… 
Review
2008
Review
2008
Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties
Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the α7 subtype is highly expressed in the hippocampus and… 
Review
2007
Review
2007
Novel High-Affinity 7 Neuronal Nicotinic Receptor Agonist : Radioligand Binding Characterization to Rat and Human Brain
Receptor binding was characterized for [H](1S,4S)-2,2-dimethyl5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane ([H… 
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