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A-484954

National Institutes of Health

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PyridinesPyrimidines

Papers overview

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2018
2018
CHARACTERIZATION OF A NOVEL ANTIEPILEPTIC THERAPY BY TARGETING THE EEF2K/EEF2 PATHWAY
4 1. ABSTRACT eEF2K (eukaryotic Elongation Factor 2 Kinase) is an ubiquitous Ca++/Calmodulinedependent kinase that regulates… 
2016
2016
NH125 reduces the level of CPEB3, an RNA binding protein, to promote synaptic GluA2 expression
2016
2016
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms
The elongation factor 2 kinase (eEF2K), likewise known as CaMKIII, has been demonstrated to be involved in antidepressant… 
2015
2015
Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells
Eukaryotic elongation factor 2 kinase (eEF2K), also known as calmodulin (CaM)‐dependent protein kinase (CaMK) III, is a unique… 
2015
2015
Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling.
Pulmonary arterial (PA) hypertension (PAH) is a progressive and lethal disease that is caused by increased vascular contractile… 
2015
2015
Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis
A-484954 is a known eEF2K inhibitor with submicromolar IC50 potency. However, the binding mechanism and the crystal structure of… 
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