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A 192621

Known as: A-192621, A192621 
National Institutes of Health

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1 relation

Broader (1)

Pyrrolidines

Papers overview

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2008
2008
Distinct modulation of the endothelin-1 pathway in iNOS-/- and eNOS-/- mice.
We hypothesized that constitutive endothelial NO synthase (eNOS) and inducible NO synthase (iNOS) have opposite effects on the… 
2004
2004
Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines
Some men treated with atrasentan (ABT‐627), an endothelin A (ETA) receptor inhibitor, had declines in their serum PSA levels. It… 
2004
2004
Effects of Selective and Non-Selective Endothelin Receptor Blockade on ET-1-Induced Pressor Response in the Hamster
In order to assess the physiological balance existing between vasoconstrictor and vasodilator endothelin-B receptor actions… 
2004
2004
Effects of ETA and ETB Receptor Blockade on Post-ischemic Cardiac Dysfunction and Norepinephrine Overflow in Isolated Rat Hearts
We investigated the role of endothelin-A (ETA) and endothelin-B (ETB) receptors in ischemia/reperfusion-induced cardiac… 
2004
2004
Effects of ET(A) and ET(B) receptor blockade on post-ischemic cardiac dysfunction and norepinephrine overflow in isolated rat hearts.
We investigated the role of endothelin-A (ETA) and endothelin-B (ETB) receptors in ischemia/reperfusion-induced cardiac… 
2002
2002
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.
Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET(A) and ET(B) receptors to… 
2001
2001
Differential modulation of endothelin ligand‐induced contraction in isolated tracheae from endothelin B (ETB) receptor knockout mice
The role of endothelin B (ETB) receptors in mediating ET ligand‐induced contractions in mouse trachea was examined in ETB… 
2001
2001
Endothelin-1–Induced Elevation in Blood Pressure Is Independent of Increases in Sympathetic Nerve Activity in Normotensive Rats
This study was performed to determine if endothelin-1 (ET-1)–induced pressor responses in urethane-anesthetized, normotensive… 
2000
2000
The Role of Endothelin inEarly Renal Cortical Reperfusionin Renal Transplantation
The role of specific endothelin receptors in the early renal reperfusion and long-term survival in renal transplantation was… 
1999
1999
Effect of SB 217242 on hypoxia-induced cardiopulmonary changes in the high altitude-sensitive rat.
The effects of SB 217242, a non-peptide endothelin (ET) receptor antagonist, were investigated against hypoxia-induced… 
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