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852A

Known as: 852-A, TLR7 Agonist 852A 
A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds… 
National Institutes of Health

Related topics

Related topics

3 relations
Dendritic CellsNCIt Antineoplastic Agent TerminologyTLR7 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Recombinant VP2 expressed in baculovirus and adjuvanted with TIR-TLR7: a vaccine candidate against infectious bursal disease virus
Currently, a variety of immunostimulatory molecules are used as adjuvants in combination with poor immunogenic recombinant… 
2015
2015
Comment on Li et al , page 766 Interleukin-6 in CLL : accelerator or brake ?
TLRs belong to the pattern recognition receptor family. TLRs are present on a variety of immune cells and are considered major… 
2012
2012
PDE4 Inhibitors Block TLR7 and TLR9-Driven Signaling, Proliferation and Cytokine Secretion in CLL Cells As Well As Proliferation Driven by Exposure to Apoptotic Cells
Abstract 1774 A growing body of literature supports the concept that at least a subset of chronic lymphocytic leukemia (CLL) B… 
2010
2010
The function of the pleckstrin homology domain in BCR–ABL-mediated leukemogenesis
The BCR–ABL tyrosine kinase is central to the pathogenesis of chronic myeloid leukemia (CML) and Philadelphia chromosome (Ph… 
2010
2010
Capítulo 15 – Rito sumaríssimo (arts. 852-A a 852-I)
2009
2009
An Exploratory Study of Systemic Administration of the Toll-like Receptor-7 Agonist 852A in Patients with Refractory Metastatic Melanoma
2008
2008
Cutaneous Pharmacodynamics of a Toll‐Like Receptor 7 Agonist, 852A, in Humans
852A is a specific toll‐like receptor 7 (TLR7) agonist. Thirty‐two healthy adults (8 subjects per group) received two 1‐g topical… 
2005
2005
Immune response activation by a Toll-like receptor 7 agonist: Results of a phase 1 study
2515 Background: 852A is a novel Toll-like receptor 7 (TLR7) agonist that stimulates plasmacytoid dendritic cells to produce… 
1989
1989
The relationship between O6-alkylguanine alkyltransferase activity and sensitivity to alkylation-induced sister chromatid exchanges in human lymphoblastoid cell lines.
We investigated the relationship between the ability to repair the O6-alkylguanine lesions and sister chromatid exchange (SCE… 
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