7-methylguanosine 5'-diphosphate

Known as: 7-methyl-GDP, 7-methylguanosine diphosphate, m(7)GDP 
 
National Institutes of Health

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Guanosine Diphosphate
analogs & derivatives

Papers overview

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2013
2013
Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.
Turnover of mRNA releases, in addition to the four regular nucleoside monophosphates, the methylated cap nucleotide in the form… (More)
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2012
2012
7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous… (More)
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2010
2010
Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site.
Overexpression and activation of the c-Src protein have been linked to the development of a wide variety of cancers. The… (More)
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2007
2007
The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond.
Eukaryotic translation initiation factor-4E (eIF4E) recognizes and binds the m(7) guanosine nucleotide at the 5' end of… (More)
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2007
2007
Picornavirus internal ribosome entry site elements can stimulate translation of upstream genes.
Certain viral and cellular mRNAs initiate translation cap-independently at internal ribosome entry site (IRES) elements… (More)
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2007
2007
After fertilization of sea urchin eggs, eIF4G is post-translationally modified and associated with the cap-binding protein eIF4E.
Release of eukaryotic initiation factor 4E (eIF4E) from its translational repressor eIF4E-binding protein (4E-BP) is a crucial… (More)
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2006
2006
Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.
The eukaryotic "scavenger" type decapping enzyme, an m(7)GpppX pyrophosphatase, is active in cellular mRNA metabolism and thereby… (More)
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2005
2005
Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2).
Tgs1 is the enzyme responsible for converting 7-methylguanosine RNA caps to the 2,2,7-trimethylguanosine cap structures of small… (More)
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2002
2002
Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extracts.
mRNA turnover is a regulated process that contributes to the steady state level of cytoplasmic mRNA. The amount of each mRNA… (More)
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2000
2000
Structural requirements for the specific recognition of an m7G mRNA cap.
7-Methylguanosine (m(7)G), also known as the mRNA "cap", is used as a molecular tag in eukaryotic cells to mark the 5' end of… (More)
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