• Publications
  • Influence
VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane.
Both the regular pattern and the typical structure of these lymphatics suggest that CAM is a suitable site to study the in vivo effects of potential lymphangiogenic factors.
The mRNA cap-binding protein eIF4E in post-transcriptional gene expression
The relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo are explored, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.
An in vivo control map for the eukaryotic mRNA translation machinery
Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway, and reveals gene duplication is implicated in the fine control of cellular protein synthesis.
Modulation of the Hepatitis C Virus RNA-dependent RNA Polymerase Activity by the Non-Structural (NS) 3 Helicase and the NS4B Membrane Protein*
Results reveal that NS3, NS4B, and NS5B can interact to form a regulatory complex that could feature in the process of HCV replication.
Regulation of fungal gene expression via short open reading frames in the mRNA 5′untranslated region
It is shown how the expression of fungal mRNAs can be controlled by ribosome interactions with short upstream open reading frames (uORFs) within the 5′untranslated region and how trans‐acting factors may participate in the regulatory mechanisms.
Posttranscriptional Control of Gene Expression in Yeast
  • J. McCarthy
  • Biology
    Microbiology and Molecular Biology Reviews
  • 1 December 1998
This article reviews the current knowledge of the cellular components and mechanisms related to translation and mRNA decay, with the emphasis on the molecular basis for rate control and gene regulation.
Dynamics and processivity of 40S ribosome scanning on mRNA in yeast
A biased bidirectional walking model of ribosomal scanning is developed that provides a framework for understanding the above observations as well as other known quantitative and qualitative features of this process.
The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability.
The data indicate that release of post-termination ribosomes promotes largely upf -independent accelerated decay, so it follows that translational termination on the 5'-UTR of a mature, non-aberrant yeast mRNA can trigger destabilization via a different pathway to that used to rid the cell of mRNAs containing premature stop codons.