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7-ethoxy-4-trifluoromethylcoumarin

Known as: 7-ethoxy-4-(trifluoromethyl)-2H-1-benzypyran-2-one, ETFC cpd 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Coumarins

Papers overview

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Highly Cited
2005
Highly Cited
2005
Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae.
A field-collected strain (MR-VL) of the two-spotted spider mite, Tetranychus urticae Koch, exhibited strong resistance to… Expand
Highly Cited
2004
Highly Cited
2004
Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes.
In this study we describe a battery of fluorescence assays for rapid measurement in intact cells of the activity of nine… Expand
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Highly Cited
2003
Highly Cited
2003
Functional characterization of cytochrome P450 2B6 allelic variants.
Cytochrome P450 (P450) 2B6 is a hepatic enzyme of potential importance for the metabolism of clinically used drugs and… Expand
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2002
2002
Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
The kinetics for the inactivation of cytochrome P450 2E1 and the mutant P450 2E1 T303A by tert-butyl acetylene (tBA) and tert… Expand
Highly Cited
2001
Highly Cited
2001
A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function.
The hydrophobic membrane-spanning domain in four cytochromes P450 2B was removed (Delta3-21) and several positive charges were… Expand
Highly Cited
1999
Highly Cited
1999
Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450.
The effects of methanol, ethanol, dimethyl sulfoxide (DMSO), and acetonitrile were studied in vitro on nine individual… Expand
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1999
1999
Inactivation of cytochrome P450 2E1 by benzyl isothiocyanate.
The cytochrome P450 enzymes constitute a family of phase I enzymes that play a prominent role in the metabolism of a great… Expand
1998
1998
High-performance liquid chromatographic method for measurement of cytochrome P450-mediated metabolism of 7-ethoxy-4-trifluoromethylcoumarin.
  • M. Morse, J. Lu
  • Journal of chromatography. B, Biomedical sciences…
  • 1998
    • Corpus ID: 13083385
An HPLC method for analysis of deethylation of 7-ethoxy-4-trifluoromethylcoumarin (ETFMC), a substrate of various enzymes of the… Expand
Highly Cited
1997
Highly Cited
1997
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.
The level of expression and interindividual variation in human hepatic microsomal cytochrome P450 (CYP) 2B6 was characterized… Expand
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Highly Cited
1993
Highly Cited
1993
A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarin.
The O-deethylation of 7-ethoxy-4-trifluoromethylcoumarin (EFC) by liver microsomes has been assessed as a method for monitoring… Expand
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