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7-benzyloxyquinoline

National Institutes of Health

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Quinolines

Papers overview

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Highly Cited
2010
Highly Cited
2010
Functional differences in the cytochrome P450 1 family enzymes from zebrafish (Danio rerio) using heterologously expressed proteins.
2008
2008
Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.
2006
2006
Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis
CYP3A4 has been subjected to random and site-directed mutagenesis to enhance peroxide-supported metabolism of several substrates… 
Highly Cited
2004
Highly Cited
2004
Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats.
Infection and inflammation impose a suppression in the expression and activity of several drug transporters and drug-metabolizing… 
Highly Cited
2002
Highly Cited
2002
Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4.
We have tested a panel of 29 cDNA-expressed rat and human enzymes with 9 fluorometric substrates to determine the P450 isoform… 
2002
2002
7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe.
The main objective of the present study was to find a fluorescent substrate probe for cytochrome P450eryF (P450eryF). P450eryF is… 
Highly Cited
2001
Highly Cited
2001
Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4.
Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin, marker substrates for cytochrome P450 3A4 are… 
2001
2001
Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450…
1. The aim of this study was to evaluate a number of derivatives of 7-hydroxy-4-trifluoromethylcoumarin (HFC) and 7… 
Highly Cited
2000
Highly Cited
2000
Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates.
Inhibition of cytochrome P450 catalytic activity is a principal mechanism for pharmacokinetic drug-drug interactions. Rapid, in… 
Highly Cited
1990
Highly Cited
1990
7-Alkoxyquinolines: new fluorescent substrates for cytochrome P450 monooxygenases.
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