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7-(2-hydroxypropyl)guanine

Known as: 7-HPG 
National Institutes of Health

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2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

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2003
2003
Dosimetry by means of DNA and hemoglobin adducts in propylene oxide-exposed rats.
2003
2003
Molecular dosimetry of N7-(2-hydroxypropyl)guanine in tissues of F344 rats after inhalation exposure to propylene oxide.
Propylene oxide (PO) is a high-volume chemical intermediate that causes a low incidence of nasal tumors in rodents exposed to… 
Review
2003
Review
2003
Risk assessment.
The results from mutagenic and carcinogenic studies of propylene oxide (PO) and the current efforts to develop molecular… 
2000
2000
Quantitation of DNA and hemoglobin adducts and apurinic/apyrimidinic sites in tissues of F344 rats exposed to propylene oxide by inhalation.
Propylene oxide (PO) is a relatively weak mutagen that induces nasal tumor formation in rats during long-term inhalation studies… 
1999
1999
32P-postlabelling of propylene oxide 1- and N(6)-substituted adenine and 3-substituted cytosine/uracil: formation and persistence in vitro and in vivo.
Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and… 
1999
1999
P-postlabelling of propylene oxide 1-and N 6-substituted adenine and 3-substituted cytosine / uracil : formation and persistence in vitro and in vivo
Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic inin vitro test systems and… 
1998
1998
Tissue distribution of DNA adducts in male Fischer rats exposed to 500 ppm of propylene oxide: quantitative analysis of 7-(2-hydroxypropyl)guanine by 32P-postlabelling.
Review
1997
Review
1997
Propylene oxide: mutagenesis, carcinogenesis and molecular dose.
Highly Cited
1972
Highly Cited
1972
Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid.
1. Propylene oxide reacts with DNA in aqueous buffer solution at about neutral pH to yield two principal products, identified as… 
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