7-(2-hydroxypropyl)guanine

Propylene oxide (PO) is a high-volume chemical intermediate that causes a low incidence of nasal tumors in rodents exposed to… (More)

Ethylene oxide (EO) and propylene oxide (PO) are direct acting mutagens with high Swain-Scott s-values, which indicate that they… (More)

The main purpose of the study was to establish the relation between exposure dose of propylene oxide (PO) and dose in various… (More)

Propylene oxide (PO) is a relatively weak mutagen that induces nasal tumor formation in rats during long-term inhalation studies… (More)

Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and… (More)

7-(2-Hydroxypropyl)guanine (7-HPG) constitutes the major adduct from alkylation of DNA by the genotoxic carcinogen, propylene… (More)

The results from mutagenic and carcinogenic studies of propylene oxide (PO) and the current efforts to develop molecular… (More)

1. Propylene oxide reacts with DNA in aqueous buffer solution at about neutral pH to yield two principal products, identified as… (More)