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7-(2-hydroxypropyl)guanine
Known as:
7-HPG
Â
Â
National Institutes of Health
Topic mentions per year
Topic mentions per year
1972-2003
0
1
2
3
1972
2003
Related topics
Related topics
1 relation
Broader (1)
Guanine
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
7-(2-hydroxypropyl)guanine
Guanine
Papers overview
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2003
2003
Molecular dosimetry of N7-(2-hydroxypropyl)guanine in tissues of F344 rats after inhalation exposure to propylene oxide.
Melva N RÃos-Blanco
,
Asoka Ranasinghe
,
Moung Sook Lee
,
Thomas H. Faller
,
Johannes Georg Filser
,
James A. Swenberg
Carcinogenesis
2003
Propylene oxide (PO) is a high-volume chemical intermediate that causes a low incidence of nasal tumors in rodents exposed to…Â
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2003
2003
Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl)guanine levels in Drosophila.
Madeleine J.M. Nivard
,
Kamila Czene
,
Dan Segerbäck
,
Ekkehart W. Vogel
Mutation research
2003
Ethylene oxide (EO) and propylene oxide (PO) are direct acting mutagens with high Swain-Scott s-values, which indicate that they…Â
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2003
2003
Dosimetry by means of DNA and hemoglobin adducts in propylene oxide-exposed rats.
Siv M Osterman-Golkar
,
Kamila Czene
,
+6 authors
Dan Segerbäck
Toxicology and applied pharmacology
2003
The main purpose of the study was to establish the relation between exposure dose of propylene oxide (PO) and dose in various…Â
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2000
2000
Quantitation of DNA and hemoglobin adducts and apurinic/apyrimidinic sites in tissues of F344 rats exposed to propylene oxide by inhalation.
Melva N RÃos-Blanco
,
Th. Faller
,
+5 authors
Jessica Swenberg
Carcinogenesis
2000
Propylene oxide (PO) is a relatively weak mutagen that induces nasal tumor formation in rats during long-term inhalation studies…Â
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1999
1999
32P-postlabelling of propylene oxide 1- and N(6)-substituted adenine and 3-substituted cytosine/uracil: formation and persistence in vitro and in vivo.
K Plná
,
R. Henrik Nilsson
,
M. Koskinen
,
Dan Segerbäck
Carcinogenesis
1999
Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and…Â
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1998
1998
Tissue distribution of DNA adducts in male Fischer rats exposed to 500 ppm of propylene oxide: quantitative analysis of 7-(2-hydroxypropyl)guanine by 32P-postlabelling.
Dan Segerbäck
,
K Plná
,
+4 authors
R. Henrik Nilsson
Chemico-biological interactions
1998
7-(2-Hydroxypropyl)guanine (7-HPG) constitutes the major adduct from alkylation of DNA by the genotoxic carcinogen, propylene…Â
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Review
1997
Review
1997
Propylene oxide: mutagenesis, carcinogenesis and molecular dose.
Melva N RÃos-Blanco
,
K Plná
,
+7 authors
Jessica Swenberg
Mutation research
1997
The results from mutagenic and carcinogenic studies of propylene oxide (PO) and the current efforts to develop molecular…Â
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1972
1972
Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid.
P D Lawley
,
Molly P Jarman
The Biochemical journal
1972
1. Propylene oxide reacts with DNA in aqueous buffer solution at about neutral pH to yield two principal products, identified as…Â
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