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667 coumate

National Institutes of Health

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irosustat

Papers overview

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2019
2019
A new class of coumate benzimidazole hybrids as BRCA-1 mimetics through unconventional binding mode; Synthesis and preliminary cytotoxicity screening.
AIMS The present work focus to identify a new class of BRCA-1 mimetics that work differently from conventional anti estrogens… 
2014
2014
Steroid sulfatase mediated growth Sof human MG-63 pre-osteoblastic cells
2007
2007
A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models
We screened a series of 17β-(N-alkylcarbamoyl)-estra-1,3,5(10)trine-3-O-sulfamate derivatives, and describe here a potent and… 
2005
2005
Inhibition of steroid sulfatase by 667 COUMATE (STX64): a new treatment paradigm for breast cancer
2004
2004
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates.
2003
2003
Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo
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