irosustat

Known as: 6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta-(c)(1)benzopyran-3-O-sulfamate, STX 64 
Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active… (More)
National Institutes of Health

Papers overview

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2017
2017
Steroid sulfatase (STS) is involved in oestrogen biosynthesis and irosustat is a first generation, irreversible steroid sulfatase… (More)
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2017
2017
Irosustat is a first-generation, orally active, irreversible steroid sulfatase inhibitor. We performed a multicentre, open label… (More)
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2014
2014
Irosustat is the ‘first-in-class’ irreversible potent steroid sulphatase inhibitor with lack of oestrogenic activity. The… (More)
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2013
2013
Steroid sulfatase (STS) inhibition may have a therapeutic role in suppression of endocrine-responsive breast cancer. This study… (More)
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2012
2012
Irosustat is a first-generation, irreversible, steroid sulfatase inhibitor currently in development for hormone-dependent cancer… (More)
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Review
2011
Review
2011
Endocrine therapy is a key modality in the management of breast cancer, with current options for postmenopausal women including… (More)
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2011
2011
Structure-activity relationship studies were conducted on Irosustat (STX64, BN83495), the first steroid sulfatase (STS) inhibitor… (More)
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2011
2011
Irosustat is a novel steroid sulfatase inhibitor for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin… (More)
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Review
2011
Review
2011
Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a… (More)
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