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6-hydroxydopa quinone

Known as: topa quinone, topaquinone 
National Institutes of Health

Related topics

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3 relations

Broader (2)

DopaLevodopa
analogs & derivatives

Papers overview

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Review
2003
Review
2003
The multi-functional topa-quinone copper amine oxidases.
Highly Cited
2001
Highly Cited
2001
The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast.
All known copper amine oxidases (CAOs) contain 2,4,5-trihydroxyphenylalanine quinone (TPQ) as a redox cofactor. TPQ is derived… 
Review
1999
Review
1999
Structure and biogenesis of topaquinone and related cofactors
  • D. Dooley
  • JBIC Journal of Biological Inorganic Chemistry
  • 1999
  • Corpus ID: 10104769
Abstract The structure of a new biological redox cofactor – topaquinone (TPQ), the quinone of 2,4,5-trihydroxyphenylalanine – was… 
1997
1997
Mechanism-based inactivation of a yeast methylamine oxidase mutant: implications for the functional role of the consensus sequence surrounding topaquinone.
The copper-containing yeast methylamine oxidase E406N mutant has an altered consensus sequence surrounding the topaquinone… 
Highly Cited
1997
Highly Cited
1997
Mechanistic studies of topa quinone biogenesis in phenylethylamine oxidase.
An alternative purification for apophenylethylamine oxidase from Arthrobacter globiformis has been developed, which avoids the… 
1996
1996
Biosynthesis of Topa Quinone Cofactor in Bacterial Amine Oxidases
Resonance Raman spectroscopy is an excellent technique for providing structural information on the 2,4,5-trihydroxyphenylalanine… 
1995
1995
Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy.
The aromatic amine oxidase from Escherichia coli (ECAO) utilizes Cu(II) and 2,4,5-trihydroxyphenylalanine quinone (TPQ) as… 
Highly Cited
1994
Highly Cited
1994
Cloning and sequencing of phenylethylamine oxidase from Arthrobacter globiformis and implication of Tyr-382 as the precursor to its covalently bound quinone cofactor.
The gene of Arthrobacter globiformis encoding a quinoprotein, phenylethylamine oxidase, has been cloned and sequenced. In the… 
1993
1993
Cloning, sequencing, expression, and regulation of the structural gene for the copper/topa quinone-containing methylamine oxidase from Arthrobacter strain P1, a gram-positive facultative methylotroph
Deoxyoligonucleotides corresponding to amino acid sequences of methylamine oxidase and polyclonal anti-methylamine oxidase… 
Highly Cited
1991
Highly Cited
1991
The organic functional group in copper-containing amine oxidases. Resonance Raman spectra are consistent with the presence of topa quinone (6-hydroxydopa quinone) in the active site.
Resonance Raman spectroscopy has been used to probe the structure of the organic cofactor in copper-containing amine oxidases… 
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