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6-ethylguanine

Known as: O(6)-ethylguanine 
National Institutes of Health

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Broader (1)

Guanine
analogs & derivatives

Papers overview

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1998
1998
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Differential repair of structurally distinct mutagenic lesions in critical genes may influence the cellular risk of malignant… 
1998
1998
Molecular dosimetry of DNA adducts in the medaka small fish model.
Small fish models are being used with increasing frequency for carcinogenicity testing and comparative cancer research in the US… 
1996
1996
Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of λlacZ transgenic mice treated with N-ethyl-N-nitrosourea
LacZ transgenic mice are suitable for short-term mutagenicity studies in vivo. Mutagenicity in these mice is determined in the… 
1991
1991
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences.
We have established a sensitive, monoclonal antibody (Mab)-based procedure permitting the selective enrichment of sequences… 
1986
1986
Cytogenetic effects induced by alkylated guanine in mammalian cells.
Cytogenetic effects of O6-ethylguanine (O6EtG) were investigated in V79 Chinese hamster cells and human lymphocytes. The… 
1986
1986
DNA ethylation in hamster tissues during subchronic diethylnitrosamine administration and in the hamster trachea after acute diethylnitrosamine administration.
Formation of O6-ethylguanine (O6EG) in trachea DNA was measured 12 h after acute i.p. administration of 50, 100 and 200 mg… 
1985
1985
Kinetics of formation and persistence of ethylguanines in DNA of rats and hamsters treated with diethylnitrosamine.
The kinetics of formation and persistence of 7-ethylguanine (e7Gua) and O6-ethylguanine (O6eGua) were determined in rat liver and… 
1984
1984
Mutagenesis and O6-ethylguanine levels in DNA from N-nitroso-N-ethylurea-treated Salmonella typhimurium: evidence for a high mutational efficiency of O6-ethylguanine.
The dose-responses for N-nitroso-N-ethylurea (NEU)-induced mutagenesis in the hisG46 mutant, Salmonella typhimurium TA1535, and… 
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