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6-ethylguanine

Known as: O(6)-ethylguanine 
National Institutes of Health

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2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nervous system by ethylnitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA…
The ethylation of nucleic acids by the nervous system-specific pulse-carcinogen N-ethyl-N-nitrosourea (ENU) was investigated in… 
Review
2000
Review
2000
Role of DNA repair in carcinogen-induced ras mutation.
1998
1998
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Differential repair of structurally distinct mutagenic lesions in critical genes may influence the cellular risk of malignant… 
Review
1998
Review
1998
Relevance of DNA repair to carcinogenesis and cancer therapy.
DNA-reactive carcinogens and anticancer drugs induce many structurally distinct cytotoxic and potentially mutagenic DNA lesions… 
1996
1996
Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context.
Double-stranded (ds) oligodeoxynucleotides (29mers) containing an O6-ethylguanine (O6-EtGua) flanked 5' and 3' by different bases… 
Highly Cited
1989
Highly Cited
1989
Purification of the E. coli ogt gene product to homogeneity and its rate of action on O6-methylguanine, O6-ethylguanine and O4-methylthymine in dodecadeoxyribonucleotides.
The E. coli gene ogt encodes the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (O6-AlkG ATase). The protein coding… 
Highly Cited
1989
Highly Cited
1989
Repair of O6-methylguanine, O6-ethylguanine, O6-isopropylguanine and O4-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O6-alkylguanine-DNA-alkyltransferase.
Self-complementary oligodeoxynucleotides have been synthesized containing O6-methylguanine (O6meG), O6-ethylguanine (O6etG), O6… 
1989
1989
O6-methyltransferase-deficient and -proficient CHO cells differ in their responses to ethyl- and methyl-nitrosourea-induced DNA alkylation.
The mutagenic and cytotoxic effects of N-ethyl-N-nitrosourea (ENU) and N-methyl-N-nitrosourea (MNU) were compared in two isogenic… 
1988
1988
Different mutational profiles induced by N‐nitroso‐N‐ethylurea: Effects of dose and error‐prone DNA repair and correlations with DNA adducts
The DNA adducts and mutational profile produced by N‐nitroso‐N‐ethylurea (ENU) in Salmonella are examined. The adduct profile… 
1985
1985
O6-Alkylguanine DNA alkyltransferase activity in monkey, human and rat liver.
Previous studies have shown that in in vitro assays using methylated DNA substrates, human and rat liver fractions were able to… 
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