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6-deoxyerythronolide B

Known as: 3,5,11-trihydroxyerythranolid-9-one, Erythronolide A, 6,12-dideoxy- 
 
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Every polyketide synthase module has an acyl carrier protein (ACP) and a ketosynthase (KS) domain that collaborate to catalyze… Expand
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Highly Cited
2009
Highly Cited
2009
Among the frontier challenges in chemistry in the twenty-first century are the interconnected goals of increasing synthetic… Expand
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Review
2007
Review
2007
6-Deoxyerythronolide B, the macrocyclic aglycone of the antibiotic erythromycin, is synthesized by a polyketide synthase (PKS… Expand
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Highly Cited
2007
Highly Cited
2007
6-Deoxyerythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthesis of 6-dEB (1), the… Expand
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Highly Cited
2007
Highly Cited
2007
We report the 2.6 A X-ray crystal structure of a 190 kDa homodimeric fragment from module 3 of the 6-deoxyerthronolide B synthase… Expand
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Highly Cited
2006
Highly Cited
2006
The x-ray crystal structure of a 194-kDa fragment from module 5 of the 6-deoxyerythronolide B synthase has been solved at 2.7 A… Expand
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2006
2006
[reaction: see text] The enantioselective synthesis of the carbon skeleton of 6-deoxyerythronolide B has been achieved in 23… Expand
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Highly Cited
2004
Highly Cited
2004
The hallmark of a type I polyketide synthase (PKS), such as the 6-deoxyerythronolide B synthase (DEBS), is the presence of… Expand
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Highly Cited
2003
Highly Cited
2003
Escherichia coli is an attractive candidate as a host for polyketide production and has been engineered to produce the… Expand
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Highly Cited
2001
Highly Cited
2001
The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by… Expand
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