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6-deoxyerythronolide B

Known as: 3,5,11-trihydroxyerythranolid-9-one, Erythronolide A, 6,12-dideoxy- 
National Institutes of Health

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Broader (1)

Erythromycin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene
An S-adenosylmethionine synthetase gene (metK) from Streptomyces spectabilis was cloned into an expression plasmid under the… 
2006
2006
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase
Precursor-directed biosynthesis has been shown to be a powerful tool for the production of polyketide analogues that would be… 
2005
2005
Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry.
Polyketide natural products are biosynthesized via successive chain-elongation events mediated by elaborate protein assemblies… 
2003
2003
6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering.
The erythromycin precursor polyketide 6-deoxyerythronolide B (6-dEB) is produced from one propionyl-CoA starter unit and six (2S… 
2000
2000
Precursor‐Directed Biosynthesis of 6‐Deoxyerythronolide B Analogs in Streptomycescoelicolor: Understanding Precursor Effects
A fermentation process employing precursor‐directed biosynthesis is being developed for the manufacture of 6‐deoxyerythronolide B… 
Highly Cited
1998
Highly Cited
1998
General Strategies toward the Syntheses of Macrolide Antibiotics. The Total Syntheses of 6-Deoxyerythronolide B and Oleandolide
The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These… 
1998
1998
Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis.
Modular polyketide synthases such as 6-deoxyerythronolide B synthase (DEBS) catalyze the biosynthesis of structurally complex… 
Highly Cited
1993
Highly Cited
1993
Substrate specificity of 6-deoxyerythronolide B hydroxylase, a bacterial cytochrome P450 of erythromycin A biosynthesis.
The 6-deoxyerythronolide B hydroxylase (EryF) is a soluble cytochrome P450 responsible for the stereospecific C-6 hydroxylation… 
Highly Cited
1992
Highly Cited
1992
Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase
Previous studies of erythromycin biosynthesis have indicated that a cytochrome P-450 monooxygenase system is responsible for… 
Highly Cited
1991
Highly Cited
1991
An acyl-carrier-protein-thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli.
The C-terminal region of a multifunctional polypeptide from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea is… 
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