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6-chlorotacrine
Known as:
6-Cl-tacrine
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Tacrine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
M. Kaniaková
,
E. Nepovimova
,
+10 authors
M. Horak
Current Alzheimer Research
2019
Corpus ID: 73514509
A novel molecule 2 formed by combining 6-chlorotacrine (6-Cl-THA) and memantine proved to be a promising multipotent hybrid…
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Highly Cited
2018
Highly Cited
2018
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
V. Hepnarova
,
J. Korábečný
,
+16 authors
O. Soukup
European journal of medicinal chemistry
2018
Corpus ID: 4684466
2017
2017
Cholinesterase Inhibitor 6-Chlorotacrine - In Vivo Toxicological Profile and Behavioural Effects.
J. Misík
,
E. Nepovimova
,
J. Pejchal
,
J. Kassa
,
J. Korábečný
,
O. Soukup
Current Alzheimer Research
2017
Corpus ID: 4969686
BACKGROUND 6-chlorotacrine is a cholinesterase inhibitor showing good inhibitory potential, even better than parent compound…
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2013
2013
A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation
Akiko Kochi
,
Todd J. Eckroat
,
Keith D. Green
,
Abdelrahman S. Mayhoub
,
M. Lim
,
S. Garneau‐Tsodikova
2013
Corpus ID: 84247720
The number of people suffering from Alzheimer's disease (AD) is expected to increase dramatically in the coming decades…
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2013
2013
Investigation of the role of linker moieties in bifunctional tacrine hybrids.
Todd J. Eckroat
,
Keith D. Green
,
R. Reed
,
J. Bornstein
,
S. Garneau‐Tsodikova
Bioorganic & Medicinal Chemistry
2013
Corpus ID: 43632362
Highly Cited
2010
Highly Cited
2010
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
P. Camps
,
Xavier Formosa
,
+16 authors
F. J. Luque
Chemico-Biological Interactions
2010
Corpus ID: 45067137
Highly Cited
2009
Highly Cited
2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
P. Camps
,
Xavier Formosa
,
+15 authors
F. J. Luque
Journal of Medicinal Chemistry
2009
Corpus ID: 42405869
Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for…
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Highly Cited
2008
Highly Cited
2008
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
P. Camps
,
Xavier Formosa
,
+15 authors
F. J. Luque
Journal of Medicinal Chemistry
2008
Corpus ID: 42481277
A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding…
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Highly Cited
2005
Highly Cited
2005
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
D. Alonso
,
I. Dorronsoro
,
+9 authors
A. Martinez
Bioorganic & Medicinal Chemistry
2005
Corpus ID: 32731268
1996
1996
Binding of tacrine and 6‐chlorotacrine by acetylcholinesterase
S. Wlodek
,
J. Antosiewicz
,
+5 authors
J. Sussman
1996
Corpus ID: 196594442
Multiconfiguration thermodynamic integration was used to determine the relative binding strength of tacrine and 6-chlorotacrine…
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