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6-chlorotacrine

Known as: 6-Cl-tacrine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Tacrine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
A novel molecule 2 formed by combining 6-chlorotacrine (6-Cl-THA) and memantine proved to be a promising multipotent hybrid… 
Highly Cited
2018
Highly Cited
2018
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
2017
2017
Cholinesterase Inhibitor 6-Chlorotacrine - In Vivo Toxicological Profile and Behavioural Effects.
BACKGROUND 6-chlorotacrine is a cholinesterase inhibitor showing good inhibitory potential, even better than parent compound… 
2013
2013
A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation
The number of people suffering from Alzheimer's disease (AD) is expected to increase dramatically in the coming decades… 
2013
2013
Investigation of the role of linker moieties in bifunctional tacrine hybrids.
Highly Cited
2010
Highly Cited
2010
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
Highly Cited
2009
Highly Cited
2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for… 
Highly Cited
2008
Highly Cited
2008
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding… 
Highly Cited
2005
Highly Cited
2005
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
1996
1996
Binding of tacrine and 6‐chlorotacrine by acetylcholinesterase
Multiconfiguration thermodynamic integration was used to determine the relative binding strength of tacrine and 6-chlorotacrine… 
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