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Formal synthesis of (-)-podophyllotoxin through the photocyclization of an axially chiral 3,4-bisbenzylidene succinate amide ester--a flow photochemistry approach.
A strategy for the stereoselective synthesis of cyclolignans related to podophyllotoxin and its derivatives and the photocyclization of a chiral atropoisomeric 1,2-bisbenzylidenesuccinate amide ester is developed.
Optimization of cultural conditions for the production of antifungal chitinase by Streptomyces sporovirgulis
Purified chitinase from S. sporovirgulis inhibited growth of fungal phytopathogen Alternaria alternata and inhibited the growth of potential phy topathogens such as Penicillium purpurogenum and Penillium sp.
Flow Photochemistry as a Tool for the Total Synthesis of (+)-Epigalcatin.
The first total synthesis of (+)-epigalcatin was completed in a highly stereoselective manner starting from piperonal, 3,4-dimethylbenzaldehyde, and diethyl succinate to construct the cyclolignan framework by continuous-flow photocyclization of a chiral atropisomeric 1,2-bisbenzylidenesuccinate amide ester.
Unusual visible-light photolytic cleavage of tertiary amides during the synthesis of cyclolignans related to podophyllotoxin
Abstract During the attempted photochemical cyclization of 2,3-bisbenzylidene-γ-hydroxybutyric acid cyclic amide ester, it was observed that a γ-butyrolactone ring was formed, which was concurrent
Unexpected regioselectivity in the photocyclization of a chiral 2,3-bisbenzylidenesuccinate, leading to a podophyllotoxin related cyclolignan
Abstract The Stobbe condensation between 3′,4′,5′-trimethoxyacetophenone and a benzylidenesuccinate derived from piperonal gave the Z,E-2,3-bisbenzylidenesuccinate as the only product. Such
Advances in the Synthesis of Aryltetralin and Arylnaphthalene Lignans using Photocyclization
Lignans are a well-known and widely distributed class of natural products with huge structural and biological diversity. They occur in many species of plants, at different levels of content, in each
Anti-prion drug screening system in Saccharomyces cerevisiae based on an artificial [LEU2+] prion.
An alternative yeast-based system to evaluate anti-prion activity of chemical compounds is presented, based on an artificial [LEU2+] prion created by fusing Leu2p with the prion-forming domain of Sup35p in Saccharomyces cerevisiae.
Novel podophyllotoxin and benzothiazole derivative induces transitional morphological and functional changes in HaCaT cells.
The KL3 derivative of PPT in contrast to PPT allows repair of normal keratinocytes and triggers mechanisms that restore non-tumor cell homeostasis and shows that KL3 is less toxic than PPT to non-cancerous cells.
Unique cyclolignan’s architecture obtained via acid catalyzed cyclization/intramolecular Friedel-Crafts tandem reaction
We examine the cyclization of chiral bis-benzylidenesuccinate 6 (precursor to podophyllotoxin-related cyclolignans) in different conditions. Under acid catalysis, a new type of cyclolignan was