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6-Aminonicotinamide

Known as: 6-Aminonicotinamide [Chemical/Ingredient], 6-AN, 6 Aminonicotinamide 
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway… 
National Institutes of Health

Related topics

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9 relations

Broader (2)

AminopyridinesTeratogens
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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Highly Cited
2010
Highly Cited
2010
Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells.
Highly Cited
2009
Highly Cited
2009
Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.
Highly Cited
2003
Highly Cited
2003
Astrocyte‐targeted expression of interleukin‐6 protects the central nervous system during neuroglial degeneration induced by 6‐aminonicotinamide
6‐Aminonicotinamide (6‐AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes mainly in the brainstem… 
Highly Cited
2003
Highly Cited
2003
A model of the oscillatory metabolism of activated neutrophils.
Highly Cited
1975
Highly Cited
1975
Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.
Highly Cited
1975
Highly Cited
1975
Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat
SummaryFocal areas of primary demyelination were produced in the spinal cords of rats by means of local injections of 6… 
Highly Cited
1974
Highly Cited
1974
Metabolic alterations in the axotomized superior cervical ganglion of the rat. II. The pentose phosphate pathway.
Highly Cited
1974
Highly Cited
1974
Cerebral energy reserves and glycolysis in neural tissue of 6-aminonicotinamide-treated mice.
Cerebral energy metabolism was studied in brains of mice treated with the nicotinamide analog, 6-aminonicotinamide (6-AN), which… 
Highly Cited
1969
Highly Cited
1969
Brain disorders induced by pharmacological blockade of the pentose phosphate pathway.
Highly Cited
1961
Highly Cited
1961
Clinical experience with 6-aminonicotinamide.
Summary The toxicity of 6-Aminonicotinamide in 60 patients with advanced malignant disease has been described. The toxicity took… 
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