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6-Aminonicotinamide

Known as: 6-Aminonicotinamide [Chemical/Ingredient], 6-AN, 6 Aminonicotinamide 
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

AminopyridinesTeratogens
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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Highly Cited
2002
Highly Cited
2002
Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6‐aminonicotinamide
6‐Aminonicotinamide (6‐AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes. Metallothionein 1+2 (MT… 
Highly Cited
2000
Highly Cited
2000
IL-6 Deficiency Leads to Reduced Metallothionein-I+II Expression and Increased Oxidative Stress in the Brain Stem after 6-Aminonicotinamide Treatment
We examined the effects of interleukin-6 (IL-6) deficiency on brain inflammation and the accompanying bone marrow (BM… 
1995
1995
Interlaboratory evaluation of embryotoxicity in the postimplantation rat embryo culture.
1983
1983
6-Aminonicotinamide-resistant mutants of Salmonella typhimurium
Resistance to the nicotinamide analog 6-aminonicotinamide has been used to identify the following three new classes of mutants in… 
Highly Cited
1974
Highly Cited
1974
Metabolic alterations in the axotomized superior cervical ganglion of the rat. II. The pentose phosphate pathway.
1974
1974
Antimetabolic Action on the Pentose Phosphate Pathway in the Central Nervous System Induced by 6-Aminonicotinamide
6-Aminonicotinamide (6-AN), an antimetabolite of nicotinamide, only differs from the naturally occurring compound by the amino… 
1972
1972
6-Aminonicotinamide (6-AN) as a Diabetogenic Agent: In Vitro and in Vivo Studies in the Rat
The effect of 6-aminonicotinamide (6-AN), an antimetabolite mainly of NADP synthesis, on insulin release, was studied. Adults… 
1968
1968
Direct effects of 6-aminonicotinamide on the developing rat embryo in vitro and in vivo.
Graded dosages of the niacin antimetabolite 6-aminonicotinamide (6-AN) were incorporated in the culture media of explanted day 10… 
1963
1963
SUBSTITUTED NICOTINAMIDE ANALOGUES OF NICOTINAMIDE ADENINE DINUCLEOTIDE.
Highly Cited
1955
Highly Cited
1955
6-Aminonicotinamide--a Potent Nicotinamide Antagonist.
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