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6-Aminonicotinamide

Known as: 6-Aminonicotinamide [Chemical/Ingredient], 6-AN, 6 Aminonicotinamide 
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway… Expand
National Institutes of Health

Papers overview

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2013
2013
The mammalian target of rapamycin complex 1 (mTORC1) is hyperactive in many human cancers and in tuberous sclerosis complex (TSC… Expand
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Highly Cited
2007
Highly Cited
2007
Reactive oxygen species (ROS) generated during inflammation are believed to play critical roles in various ocular diseases… Expand
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Highly Cited
2004
Highly Cited
2004
Summary6-aminonicotinamide, a potent antimetabolite of nicotinamide, produces, in lower doses of 5–10 mg/kg, selective damage of… Expand
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Highly Cited
2003
Highly Cited
2003
6‐Aminonicotinamide (6‐AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes mainly in the brainstem… Expand
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Highly Cited
1975
Highly Cited
1975
SummaryFocal areas of primary demyelination were produced in the spinal cords of rats by means of local injections of 6… Expand
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Highly Cited
1973
Highly Cited
1973
The morphology of physiological cell death and of necroses caused by treatment with various embryotoxic substances… Expand
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Highly Cited
1970
Highly Cited
1970
6Aminonicotinamide (6AN) can replace the nicotinamide moiety of pyridine nucleotides both in vitro and in vivo in the reaction… Expand
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Highly Cited
1969
Highly Cited
1969
Abstract 6-ANADP synthesized by the endoplasmic glycohydrolase in the brain cells of rats after application of 6-AN is an… Expand
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Highly Cited
1961
Highly Cited
1961
Summary The toxicity of 6-Aminonicotinamide in 60 patients with advanced malignant disease has been described. The toxicity took… Expand
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Highly Cited
1958
Highly Cited
1958
6-Aminonicotinamide has been reported to be a powerful niacin antagonist (1) and effective against certain experimental neoplasms… Expand
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