5-hydroxyuracil

Background: Nei is a DNA glycosylase of the base excision repair pathway. Results: We present two crystal structures of an Nei… Expand

Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… Expand

Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… Expand

The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil, are readily bypassed, miscode, and… Expand

The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious… Expand

Thymine glycol, a potentially lethal DNA lesion produced by reactive oxygen species, can be removed by DNA glycosylase… Expand

Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD). The… Expand

The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… Expand

Oxidative stress may contribute to neuronal loss in Alzheimer's disease (AD). The present study compares the levels of oxidative… Expand

Exposure of calf thymus DNA to hypochlorous acid/hypochlorite leads to extensive DNA base modification. Large concentration… Expand