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5-hydroxyuracil

Known as: 2,4,5(3H)-Pyrimidinetrione, dihydro- 
National Institutes of Health

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2 relations

Broader (1)

Uracil
analogs & derivatives

Papers overview

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2008
2008
Base excision repair activities in organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation.
Highly Cited
2007
Highly Cited
2007
Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences
Evidence has emerged that repair of clustered DNA lesions may be compromised, possibly leading to the formation of double-strand… 
2006
2006
Formation of isodialuric acid lesion within DNA oligomers via one-electron oxidation of 5-hydroxyuracil: characterization, stability and excision repair
5-Hydroxyuracil is a major oxidized nucleobase that can be generated by the action of •OH radical and one-electron oxidants. The… 
2006
2006
Ab initio base-pairing energies of uracil and 5-hydroxyuracil with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
Oxidized cytosine product 5-hydroxyuracil has been shown to be the major chemical precursor for the GC to AT transition, the most… 
Highly Cited
2000
Highly Cited
2000
Comparison of substrate specificities of Escherichia coli endonuclease III and its mouse homologue (mNTH1) using defined oligonucleotide substrates.
Escherichia coli endonuclease III (Endo III) and its eukaryotic homologues are major repair enzymes for pyrimidine lesions formed… 
1998
1998
Substrate specificity of Schizosaccharomyces pombe Nth protein for products of oxidative DNA damage.
A gene from Schizosaccharomyces pombe, which encodes a protein with a strong sequence similarity to the Nth protein of… 
1997
1997
Synthesis and cleavage of oligodeoxynucleotides containing a 5-hydroxyuracil residue at a defined site.
Oxidation and hydrolysis of a cytosine residue can lead to the formation of 5-hydroxyuracil in DNA. The biological consequences… 
1996
1996
Excision of oxidative cytosine modifications from gamma-irradiated DNA by Escherichia coli endonuclease III and human whole-cell extracts.
The possible release from gamma-irradiated DNA of eight oxidatively modified cytosine bases by Escherichia coli endonuclease III… 
Highly Cited
1995
Highly Cited
1995
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Highly Cited
1986
Highly Cited
1986
Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide.
OsO4 selectively forms thymine glycol lesions in DNA. In the past, OsO4-treated DNA has been used as a substrate in studies of… 
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