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5-hydroxyuracil

Known as: 2,4,5(3H)-Pyrimidinetrione, dihydro- 
 
National Institutes of Health

Papers overview

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2011
2011
Background: Nei is a DNA glycosylase of the base excision repair pathway. Results: We present two crystal structures of an Nei… Expand
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Review
2007
Review
2007
Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… Expand
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Highly Cited
2003
Highly Cited
2003
Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… Expand
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Review
2002
Review
2002
The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil, are readily bypassed, miscode, and… Expand
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Highly Cited
2002
Highly Cited
2002
The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious… Expand
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Highly Cited
2002
Highly Cited
2002
Thymine glycol, a potentially lethal DNA lesion produced by reactive oxygen species, can be removed by DNA glycosylase… Expand
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Highly Cited
1998
Highly Cited
1998
Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD). The… Expand
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Highly Cited
1998
Highly Cited
1998
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… Expand
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Highly Cited
1997
Highly Cited
1997
Oxidative stress may contribute to neuronal loss in Alzheimer's disease (AD). The present study compares the levels of oxidative… Expand
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Highly Cited
1997
Highly Cited
1997
Exposure of calf thymus DNA to hypochlorous acid/hypochlorite leads to extensive DNA base modification. Large concentration… Expand
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