5-hydroxyuracil

Known as: 2,4,5(3H)-Pyrimidinetrione, dihydro- 
 
National Institutes of Health

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2012
2012
Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by… (More)
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2007
2007
5-Hydroxyuracil (5-OHU) in DNA, arising during endogenous DNA damage and caused by ionizing radiation, is removed by the base… (More)
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Review
2007
Review
2007
Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… (More)
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2006
2006
Oxidative lesions represent the most abundant DNA lesions within the cell. In the present study, we investigated the impact of… (More)
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Highly Cited
2003
Highly Cited
2003
Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… (More)
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2002
2002
The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious… (More)
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Highly Cited
1998
Highly Cited
1998
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… (More)
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Highly Cited
1998
Highly Cited
1998
Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD). The… (More)
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1995
1995
Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6… (More)
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1994
1994
alpha-Interferon (IFN alpha) potentiates the cytotoxicity of 5-fluorouracil (FUra) in vitro, and the combination has clinical… (More)
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