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5-hydroxyuracil

Known as: 2,4,5(3H)-Pyrimidinetrione, dihydro- 
National Institutes of Health

Related topics

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2 relations

Broader (1)

Uracil
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Base excision repair of oxidative DNA damage and association with cancer and aging.
Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species… Expand
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Review
2007
Review
2007
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… Expand
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Highly Cited
2003
Highly Cited
2003
Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2*
Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… Expand
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Review
2002
Review
2002
Biological consequences of free radical-damaged DNA bases.
  • S. Wallace
  • Free radical biology & medicine
  • 2002
    • Corpus ID: 11852794
The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil, are readily bypassed, miscode, and… Expand
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Highly Cited
2002
Highly Cited
2002
Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions*
Two candidate human orthologs ofEscherichia coli MutM/Nei were recently identified in the human genome database, and one of these… Expand
Highly Cited
2002
Highly Cited
2002
Alternative nucleotide incision repair pathway for oxidative DNA damage
The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious… Expand
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Highly Cited
1998
Highly Cited
1998
Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease
Abstract: Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD… Expand
Highly Cited
1998
Highly Cited
1998
Oxidized, deaminated cytosines are a source of C --> T transitions in vivo.
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… Expand
Highly Cited
1997
Highly Cited
1997
An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease
Abstract: Oxidative stress may contribute to neuronal loss in Alzheimer's disease (AD). The present study compares the levels of… Expand
Highly Cited
1997
Highly Cited
1997
Hypochlorous acid-induced base modifications in isolated calf thymus DNA.
Exposure of calf thymus DNA to hypochlorous acid/hypochlorite leads to extensive DNA base modification. Large concentration… Expand
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