5-hydroxyuracil

Known as: 2,4,5(3H)-Pyrimidinetrione, dihydro- 
 
National Institutes of Health

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Broader (1)

Uracil
analogs & derivatives

Papers overview

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2012
2012
Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.
Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by… (More)
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2007
2007
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.
5-Hydroxyuracil (5-OHU) in DNA, arising during endogenous DNA damage and caused by ionizing radiation, is removed by the base… (More)
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Review
2007
Review
2007
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… (More)
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2006
2006
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors.
Oxidative lesions represent the most abundant DNA lesions within the cell. In the present study, we investigated the impact of… (More)
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Highly Cited
2003
Highly Cited
2003
Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.
Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… (More)
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2002
2002
Alternative nucleotide incision repair pathway for oxidative DNA damage
The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious… (More)
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Highly Cited
1998
Highly Cited
1998
Oxidized, deaminated cytosines are a source of C --> T transitions in vivo.
The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… (More)
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Highly Cited
1998
Highly Cited
1998
Increased nuclear DNA oxidation in the brain in Alzheimer's disease.
Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD). The… (More)
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1995
1995
Oxidative damage to 5-methylcytosine in DNA.
Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6… (More)
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1994
1994
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine…
alpha-Interferon (IFN alpha) potentiates the cytotoxicity of 5-fluorouracil (FUra) in vitro, and the combination has clinical… (More)
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