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Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species… Expand Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… Expand Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… Expand The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil, are readily bypassed, miscode, and… Expand Two candidate human orthologs ofEscherichia coli MutM/Nei were recently identified in the human genome database, and one of these… Expand The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious… Expand Abstract: Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD… Expand The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… Expand Abstract: Oxidative stress may contribute to neuronal loss in Alzheimer's disease (AD). The present study compares the levels of… Expand Exposure of calf thymus DNA to hypochlorous acid/hypochlorite leads to extensive DNA base modification. Large concentration… Expand