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Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer… Expand Iron has a pivotal and dual role in free radical chemistry in all organisms. On the one hand, free Fe can participate in Fenton… Expand The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil, are readily bypassed, miscode, and… Expand Two candidate human orthologs ofEscherichia coli MutM/Nei were recently identified in the human genome database, and one of these… Expand Abstract: Multiple lines of evidence indicate that oxidative stress is a contributor to neuronal death in Alzheimer's disease (AD… Expand The most common base substitution arising from oxidative damage of DNA is a GC --> AT transition. In an effort to determine the… Expand Two major stable oxidation products of 2'-deoxycytidine are 2'-deoxy-5-hydroxycytidine (5-OHdC) and 2'-deoxy-5-hydroxyuridine (5… Expand Ferric nitrilotriacetate (Fe‐NTA) causes renal proximal tubular necrosis, a consequence of iron ion‐mediated free‐radical… Expand Free radical‐induced damage to DNA in vivo is implicated to play a role in carcinogenesis. Evidence exists that DNA damage by… Expand DNA damage induced by oxygen radicals, e.g., hydroxyl radicals generated in living cells either by cellular metabolism or… Expand