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5-carboxamido-5-formamido-2-iminohydantoin

 
National Institutes of Health

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Hydantoins

Papers overview

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2015
2015
5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing…
Exogenously and endogenously produced reactive oxygen species attack the base and sugar moieties of DNA showing a preference for… Expand
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2015
2015
Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.
Guanine (G) is a target for oxidation by reactive oxygen species in DNA, RNA, and the nucleotide pool. Damage to DNA yields… Expand
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2015
2015
Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin.
Oxidation of the guanine heterocycle by two electrons can yield the chiral product 5-carboxamido-5-formamido-2-iminohydantoin… Expand
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2015
2015
Rates of Chemical Cleavage of DNA and RNA Oligomers Containing Guanine Oxidation Products
The nucleobase guanine in DNA (dG) and RNA (rG) has the lowest standard reduction potential of the bases, rendering it a major… Expand
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2013
2013
G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.
Telomere shortening occurs during oxidative and inflammatory stress with guanine (G) as the major site of damage. In this work, a… Expand
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2013
2013
Computational prediction of one-electron reduction potentials and acid dissociation constants for guanine oxidation intermediates and products.
Reduction potentials and pK(a) values were calculated for intermediates and products along three major pathways for guanine… Expand
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2012
2012
Lifetimes and reaction pathways of guanine radical cations and neutral guanine radicals in an oligonucleotide in aqueous solutions.
The exposure of guanine in the oligonucleotide 5'-d(TCGCT) to one-electron oxidants leads initially to the formation of the… Expand
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2011
2011
Characterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts.
Reactive oxygen species attack both base and sugar moieties in DNA with a preference among the bases for reaction at guanine. In… Expand
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2009
2009
Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants.
The oxidation of guanine to 5-carboxamido-5-formamido-2-iminohydantoin (2-Ih) is shown to be a major transformation in the… Expand
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2006
2006
A 2-iminohydantoin from the oxidation of guanine.
The nucleobase guanine was oxidized with dimethyldioxirane (DMDO) to explore the role of epoxidizing agents in oxidative DNA… Expand
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