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This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP… Expand It has been previously shown that intrinsic metabolites can be imaged based on their water proton exchange rates using saturation… Expand 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of… Expand 1. In the preceding paper (Crone, Hultborn, Kiehn, Mazieres & Wigström, 1988) it was shown that a short‐lasting synaptic… Expand The differential projections from the dorsal raphe and median raphe nuclei of the midbrain were autoradiographically traced in… Expand The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte… Expand The roles played by the cerebral monoamines (dopamine, noradrenaline and serotonin) in stimulation-produced analgesia (SPA) have… Expand 1. An acid ninhydrin reagent was found to react specifically in forming a pink product (E(max.) 560mmu) with cysteine. 2. The… Expand THE depletion by reserpine of storage in the body of 5-hydroxytryptamine (‘Serotonin’) and of the catechol amines is now well… Expand THE presence of serotonin in brain was first demonstrated by bioassay techniques (TWAROG and PAGE, 1953; AMIN, CRAWFORD, and… Expand