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5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha

Known as: AMPK Alpha, PRKAA, AMPK Subunit Alpha 
A family comprised of two proteins that can each act as the catalytic alpha subunit for the 5'-AMP-activated protein kinase (AMPK) complex. The AMPK… 
National Institutes of Health

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6 relations
AMP-Activated Protein KinasesNUAK1 protein, humanPhosphorylationPhosphotransferases

Papers overview

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Highly Cited
2010
Highly Cited
2010
Reduction of AMP-Activated Protein Kinase &agr;2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo
Background— Aberrant endoplasmic reticulum (ER) stress is associated with several cardiovascular diseases, including… 
Highly Cited
2010
Highly Cited
2010
Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK.
Reactive oxygen species (ROS) and nitric oxide (NO) have been implicated in the regulation of skeletal muscle glucose uptake… 
Highly Cited
2009
Highly Cited
2009
Curcumin disrupts the Mammalian target of rapamycin-raptor complex.
Curcumin (diferuloylmethane), a polyphenol natural product of the plant Curcuma longa, is undergoing early clinical trials as a… 
Highly Cited
2008
Highly Cited
2008
Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats.
Exercise training is commonly prescribed for treatment of nonalcoholic fatty liver disease (NAFLD). We sought to determine… 
Highly Cited
2007
Highly Cited
2007
LKB1 and AMPK maintain epithelial cell polarity under energetic stress
LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and… 
Highly Cited
2005
Highly Cited
2005
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism.
Highly Cited
2005
Highly Cited
2005
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics.
Adiponectin is an adipocyte-derived hormone associated with antidiabetic actions. In rodent skeletal muscle, globular adiponectin… 
Highly Cited
2004
Highly Cited
2004
AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells*
The antidiabetic drug metformin stimulates AMP-activated protein kinase (AMPK) activity in the liver and in skeletal muscle. To… 
Highly Cited
2004
Highly Cited
2004
Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase.
AMPK (AMP-activated protein kinase) responds to intracellular ATP depletion, while PPARalpha (peroxisome proliferator-activated… 
Highly Cited
1999
Highly Cited
1999
Arabidopsis thaliana proteins related to the yeast SIP and SNF4 interact with AKINalpha1, an SNF1-like protein kinase.
AKINalpha1, a Ser/Thr kinase from Arabidopsis thaliana belongs to the highly conserved SNF1 family of protein kinases in… 
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