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450191-S
Known as:
S 450191
, S-450191
National Institutes of Health
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rilmazafone
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1987
1987
An enzyme immunoassay for a metabolite of a new sleep inducer (450191-S), a ring-opened derivative of 1,4-benzodiazepine, in human serum.
G. Kominami
,
H. Matsumoto
,
M. Nakamura
,
M. Kono
Journal of Immunoassay
1987
Corpus ID: 39737665
A competitive enzyme immunoassay was developed for metabolites of 450191-S, a ring-opened derivative of triazolobenzodiazepines…
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1987
1987
[Pharmacology of a new sleep-inducer, a 1H-1,2,4-triazolyl benzophenone derivative, 450191-S (VIII). Examination and determination of metabolites in human plasma and urine].
T. Yamaguchi
,
M. Nakanishi
,
+7 authors
K. Sugeno
Nihon yakurigaku zasshi. Folia pharmacologica…
1987
Corpus ID: 37002460
Oral administration of 450191-S to humans at 4 mg/man led to the formation of the same plasma metabolites as those found in…
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1986
1986
Intestinal activation of a new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative, in rats.
M. Koike
,
R. Norikura
,
K. Sugeno
Journal of Pharmacobio-Dynamics
1986
Corpus ID: 41166690
5-[(2- Aminoacetamide)methyl]-1-[p-chloro-2-(o-chlorobenzoyl)phenyl]- N,N-dimethyl-1 H-s-triazole-3-carboxamide hydrochloride…
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1986
1986
Uptake of 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative, in the everted sac of rat small intestine: role of intestinal aminopeptidases.
M. Koike
,
M. Nakanishi
,
K. Sugeno
Journal of Pharmacobio-Dynamics
1986
Corpus ID: 24682419
5-[(2-Aminoacetamido)methyl]-1-[p-chloro-2-(o-chlorobenzoyl)phenyl ]-N,N-dimethyl-1 H-1,2,4-triazole-3-carboxamide hydrochloride…
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1986
1986
Induction of rat liver microsomal drug-metabolizing enzymes by a new sleep inducer 450191-S and plasma levels of 450191-S-metabolites.
T. Matsubara
,
A. Touchi
,
N. Yamada
,
K. Sugeno
Journal of Pharmacobio-Dynamics
1986
Corpus ID: 2275773
Liver microsomal 7-alkoxycoumarin O-dealkylase activities in rats were stimulated by the administration of large doses of 5-[(2…
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1986
1986
Effect of food on absorption of 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative from rat small intestine.
M. Koike
,
R. Norikura
,
K. Sugeno
Journal of Pharmacobio-Dynamics
1986
Corpus ID: 38653373
5-[(2-Aminoacetamide)methyl]-1-[p-chloro-2-(o-chlorobenzoyl)phenyl]- N, N-dimethyl-1 H-s-triazole-3-carboxamide hydrochloride…
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1986
1986
[Electroencephalographic effects of 450191-S and its metabolites in rabbits with chronic electrode implants].
S. Watanabe
,
H. Ohta
,
Y. Sakurai
,
K. Takao
,
S. Ueki
Nihon yakurigaku zasshi. Folia pharmacologica…
1986
Corpus ID: 398881
Electroencephalographic (EEG) effects of 450191-S and its metabolites were investigated in unanesthetized rabbits with chronic…
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1985
1985
[Effect of a new sleep inducer, 1H-1,2,4-triazolyl benzophenone derivative 450191-S on rat liver drug-metabolizing enzyme system].
T. Matsubara
,
A. Touchi
,
N. Yamada
,
S. Nishiyama
Nihon yakurigaku zasshi. Folia pharmacologica…
1985
Corpus ID: 19861671
The effect of a new sleep inducer, 450191-S, on the hepatic drug-metabolizing enzyme system was examined using rats and compared…
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1984
1984
[Pharmacological studies of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivatives (450191-S) (I). Behavioral analysis].
K. Yamamoto
,
K. Hirose
,
+7 authors
Y. Tsukinoki
Nihon yakurigaku zasshi. Folia pharmacologica…
1984
Corpus ID: 13578240
The behavioral effects of 450191-S and its metabolites were investigated in mice, rats, cats and rhesus monkeys, and they were…
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1984
1984
[Pharmacology of a new sleep inducer, 1H-1,2,4-triazolyl benzophenone derivative, 450191-S (II). Sleep-inducing activity and effect on the motor system].
K. Yamamoto
,
A. Matsushita
,
+7 authors
H. Koshida
Nihon yakurigaku zasshi. Folia pharmacologica…
1984
Corpus ID: 10314446
The sleep-inducing activity and effect on the motor system of the 1H-1,2,4-triazolyl benzophenone derivative 450191-S were…
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