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4-oxo-2-nonenal

Known as: 4-oxonon-2-enal 
National Institutes of Health

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1 relation

Broader (1)

Aldehydes

Papers overview

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2015
2015
Site-Specific, Intramolecular Cross-Linking of Pin1 Active Site Residues by the Lipid Electrophile 4-Oxo-2-nonenal
Products of oxidative damage to lipids include 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE), both of which are cytotoxic… 
Highly Cited
2011
Highly Cited
2011
Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction.
2011
2011
Genotoxic analysis of four lipid-peroxidation products in the mouse lymphoma assay.
2010
2010
Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal.
In this study, we examined the substrate specificity, inhibitor sensitivity and kinetic mechanism of a rat aldose reductase-like… 
2009
2009
The essential role of ERK in 4‐oxo‐2‐nonenal‐mediated cytotoxicity in SH‐SY5Y human neuroblastoma cells
Lipid peroxidation byproducts, such as 4‐hydroxynonenal (HNE) and 4‐oxo‐2‐nonenal (ONE), induce cell death in a wide variety of… 
Highly Cited
2007
Highly Cited
2007
Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides.
There has been significant recent interest in the protein reactivity and biological activity of 4-oxo-2-nonenal (ONE), the 4-keto… 
2007
2007
Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal
Abstract Substantial work has been carried out to elucidate the nature of protein modification by 4-hydroxy-2-nonenal (HNE) and… 
2003
2003
Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal.
Recent studies found that 4-oxonon-2-enal (4ONE) is a highly reactive product of lipid peroxidation that can modify peptides and… 
Highly Cited
2000
Highly Cited
2000
Formation of a substituted 1,N(6)-etheno-2'-deoxyadenosine adduct by lipid hydroperoxide-mediated generation of 4-oxo-2-nonenal.
Analysis of the reaction between 2'-deoxyadenosine and 13-hydroperoxylinoleic acid by liquid chromatography/constant neutral loss… 
Highly Cited
1999
Highly Cited
1999
Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipid peroxidation.
Two major products (adducts A and B) from the reaction of 2-deoxyguanosine (dGuo) with 13-hydroperoxylinoleic acid were detected… 
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