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4-oxalocrotonate tautomerase

Known as: 4-oxalocrotonate isomerase 
National Institutes of Health

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Isomerase

Papers overview

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2012
2012
Catalytic mechanism of 4-oxalocrotonate tautomerase: significances of protein-protein interactions on proton transfer pathways.
4-Oxalocrotonate tautomerase (4-OT), a member of tautomerase superfamily, is an essential enzyme in the degradative metabolism… 
2006
2006
Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: a computational study.
The effect of replacing arginine residues (Arg) with citrulline residues (Cit) in the binding site of 4-oxalocrotonate… 
Highly Cited
2004
Highly Cited
2004
The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment.
The role of polypeptide backbone interactions in 4-oxalocrotonate tautomerase (4OT) catalysis has been investigated using a… 
2004
2004
4-Oxalocrotonate tautomerase, its homologue YwhB, and active vinylpyruvate hydratase: synthesis and evaluation of 2-fluoro substrate analogues.
A series of 2-fluoro-4-alkene and 2-fluoro-4-alkyne substrate analogues were synthesized and examined as potential inhibitors of… 
Highly Cited
2003
Highly Cited
2003
Ab initio QM/MM study shows there is no general acid in the reaction catalyzed by 4-oxalocrotonate tautomerase.
The mechanism for the reaction catalyzed by the 4-oxalocrotonate tautomerase (4-OT) enzyme has been studied using a quantum… 
Highly Cited
2003
Highly Cited
2003
The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities.
4-Oxalocrotonate tautomerase (4-OT) catalyzes the conversion of 2-oxo-4E-hexenedioate to 2-oxo-3E-hexenedioate through the… 
2003
2003
Comparative analysis of two different amide-to-ester bond mutations in the beta-sheet of 4-oxalocrotonate tautomerase.
Here we describe the total chemical synthesis and biophysical characterization of two backbone-modified, ester bond-containing… 
2002
2002
Mutants of 4‐Oxalocrotonate Tautomerase Catalyze the Decarboxylation of Oxaloacetate through an Imine Mechanism
A designed single amino acid substitution can alter the catalytic activity and mechanism of 4‐oxalocrotonate tautomerase (4‐OT… 
2002
2002
Thermodynamic stability measurements on multimeric proteins using a new H/D exchange‐ and matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry‐based method
We recently reported on a new H/D exchange‐ and matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry‐based… 
2001
2001
Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).
4-Oxalocrotonate tautomerase (4-OT) is a bacterial enzyme that is comprised of 6 identical 62 amino acid subunits. The 4-OT… 
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