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4-oxalocrotonate tautomerase
Known as:
4-oxalocrotonate isomerase
National Institutes of Health
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1 relation
Broader (1)
Isomerase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Catalytic mechanism of 4-oxalocrotonate tautomerase: significances of protein-protein interactions on proton transfer pathways.
Pan Wu
,
G. Cisneros
,
Hao Hu
,
R. Chaudret
,
Xiangqian Hu
,
Weitao Yang
Journal of Physical Chemistry B
2012
Corpus ID: 5127468
4-Oxalocrotonate tautomerase (4-OT), a member of tautomerase superfamily, is an essential enzyme in the degradative metabolism…
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2006
2006
Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: a computational study.
T. Tuttle
,
E. Keinan
,
W. Thiel
Journal of Physical Chemistry B
2006
Corpus ID: 42042881
The effect of replacing arginine residues (Arg) with citrulline residues (Cit) in the binding site of 4-oxalocrotonate…
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Highly Cited
2004
Highly Cited
2004
The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment.
G. Cisneros
,
Min Wang
,
P. Silinski
,
M. Fitzgerald
,
Weitao Yang
Biochemistry
2004
Corpus ID: 37398818
The role of polypeptide backbone interactions in 4-oxalocrotonate tautomerase (4OT) catalysis has been investigated using a…
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2004
2004
4-Oxalocrotonate tautomerase, its homologue YwhB, and active vinylpyruvate hydratase: synthesis and evaluation of 2-fluoro substrate analogues.
W. Johnson
,
Susan C Wang
,
+5 authors
C. P. Whitman
Biochemistry
2004
Corpus ID: 21340170
A series of 2-fluoro-4-alkene and 2-fluoro-4-alkyne substrate analogues were synthesized and examined as potential inhibitors of…
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Highly Cited
2003
Highly Cited
2003
Ab initio QM/MM study shows there is no general acid in the reaction catalyzed by 4-oxalocrotonate tautomerase.
G. Cisneros
,
Haiyan Liu
,
Yingkai Zhang
,
Weitao Yang
Journal of the American Chemical Society
2003
Corpus ID: 9805450
The mechanism for the reaction catalyzed by the 4-oxalocrotonate tautomerase (4-OT) enzyme has been studied using a quantum…
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Highly Cited
2003
Highly Cited
2003
The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities.
Susan C Wang
,
W. Johnson
,
C. P. Whitman
Journal of the American Chemical Society
2003
Corpus ID: 1220534
4-Oxalocrotonate tautomerase (4-OT) catalyzes the conversion of 2-oxo-4E-hexenedioate to 2-oxo-3E-hexenedioate through the…
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2003
2003
Comparative analysis of two different amide-to-ester bond mutations in the beta-sheet of 4-oxalocrotonate tautomerase.
P. Silinski
,
M. Fitzgerald
Biochemistry
2003
Corpus ID: 12684183
Here we describe the total chemical synthesis and biophysical characterization of two backbone-modified, ester bond-containing…
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2002
2002
Mutants of 4‐Oxalocrotonate Tautomerase Catalyze the Decarboxylation of Oxaloacetate through an Imine Mechanism
A. Brik
,
L. D'Souza
,
E. Keinan
,
F. Grynszpan
,
P. Dawson
ChemBioChem
2002
Corpus ID: 38337843
A designed single amino acid substitution can alter the catalytic activity and mechanism of 4‐oxalocrotonate tautomerase (4‐OT…
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2002
2002
Thermodynamic stability measurements on multimeric proteins using a new H/D exchange‐ and matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry‐based method
K. D. Powell
,
T. Wales
,
M. Fitzgerald
Protein Science
2002
Corpus ID: 37429319
We recently reported on a new H/D exchange‐ and matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry‐based…
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2001
2001
Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).
P. Silinski
,
Michael J. Allingham
,
Michael C. Fitzgerald
Biochemistry
2001
Corpus ID: 32435593
4-Oxalocrotonate tautomerase (4-OT) is a bacterial enzyme that is comprised of 6 identical 62 amino acid subunits. The 4-OT…
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