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4-ketocyclophosphamide

Known as: 2-(bis(2-chloroethyl)amino)tetrahydro-4H-1,3,2-oxazaphosphorin-4-one 2-oxide 
National Institutes of Health

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Broader (1)

Cyclophosphamide
analogs & derivatives

Papers overview

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2005
2005
Formation of 4-ketocyclophosphamide by the oxidation of cyclophosphamide with KMnO4
Oxydation des (32P) Cyclophosphamides durch KMnO4 in Wasser oder Aceton führt zu 4-Ketocyclophosphamid und einem N-dechloro… 
2004
2004
Über Blutspiegel und Urin-Ausscheidung von aktiviertem Cyclophosphamid und seinen Deaktivierungsprodukten beim Menschen
SummaryBlood levels and urinary excretion of cyclophosphamide and its metabolites were determined in cancer patients receiving… 
2004
2004
Metabolism of high doses of cyclophosphamide
SummaryThe excretion of cyclophosphamide and the enzymatically derived metabolites 4-ketocyclophosphamide and carboxyphosphamide… 
2004
2004
Zur Bindung von Cyclophosphamid und Cyclophosphamid-Metaboliten an Serum-Albumin
Cyclophosphamide and some of its major metabolites were dialyzed against bovine-serum-albumin and human-blood-serum until… 
Review
1983
Review
1983
Teratology testing: I. Development and status of short-term prescreens. II. Biotransformation of teratogens as studied in whole embryo culture.
The development and role of short-term prescreening tests have been described and discussed in the first section. In the second… 
1981
1981
Relative mutagenicity of some urinary metabolites of the antitumor drug cyclophosphamide.
Four urinary metabolites of the cytostatic drug cyclophosphamide were tested for mutagenicity in the Ames Salmonella assay… 
1979
1979
Comparative metabolism of 2-[bis(2-chloroethyl)amino]tetrahydro-2-H-1,3,2-oxazaphosphorine-2-oxide (cyclophosphamide) and its enantiomers in humans.
The comparative metabolism of the enantiomers of cyclo phosphamide and of the racemate has been studied in humans. Four patients… 
1977
1977
Application of deuterium labelling mass spectrometry in a study of the metabolism of the enantiomers of cyclophosphamide.
The antitumour agent cyclophosphamide—{2-[bis(2-chloroethyl)amino]-tetrahydro-2H -1,3,2-oxaza-phosphorine 2-oxide}—is chiral… 
1973
1973
Cyclophosphamide structure. Molecular structure of 4-ketocyclophosphamide.
1971
1971
4-Ketocyclophosphamide, a metabolite of cyclophosphamide. Formation, chemical and biological properties.