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4-hydroxypropranolol

Known as: 1-(4-hydroxynaphth-1-yloxy)-3-isopropylamino-2- propanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-1-naphthalenol 
National Institutes of Health

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2 relations

Broader (1)

Propranolol
analogs & derivatives

Papers overview

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Highly Cited
1995
Highly Cited
1995
Propranolol disposition in Chinese subjects of different CYP2D6 genotypes
1991
1991
Stereoselective sulfate conjugation of racemic 4-hydroxypropranolol by human and rat liver cytosol.
The objective of this study was to determine the stereochemistry of sulfoconjugation of a chiral phenolic amine drug, 4… 
Highly Cited
1989
Highly Cited
1989
Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities
The relative contributions of the debrisoquin and mephenytoin isozymes of hepatic cytochrome P‐450 to the stereoselective… 
Highly Cited
1984
Highly Cited
1984
Polymorphic ability to metabolize propranolol alters 4‐hydroxypropranolol levels but not beta blockade
The ability to hydroxylate debrisoquine is known to be polymorphically distributed, with about 8% to 9% of the North American… 
Highly Cited
1982
Highly Cited
1982
Plasma levels of (+) and (-)-propranolol and 4-hydroxypropranolol after administration of racemic (+/-)-propranolol in man.
1 We have given fifteen healthy volunteers single doses of racemic (+/-)-propranolol orally (40 mg) and intravenously (5-10 mg… 
1981
1981
Combined high-performance liquid chromatographic procedure for measuring 4-hydroxypropranolol and propranolol in plasma: pharmacokinetic measurements following conventional and slow-release…
An assay is described for the simultaneous determination of propranolol and its active metabolite, 4-hydroxypropranolol, in human… 
Highly Cited
1980
Highly Cited
1980
4‐Hydroxypropranolol and its glucuronide after single and long‐term doses of propranolol
The disposition of the pharmacologically active 4‐hydroxypropranolol (HO‐P), its glucuronic acid conjugate (HO‐P‐G), and… 
1979
1979
Plasma concentrations of propranolol and 4-hydroxypropranolol during chronic oral propranolol therapy.
1 The plasma levels of propranolol and 4-hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral… 
Review
1979
Review
1979
Clinical Pharmacokinetics of Propranolol
Propranolol is completely absorbed after oral administration and widely distributed throughout tissues. Elimination occurs almost… 
Highly Cited
1971
Highly Cited
1971
Pharmacology of 4‐hydroxypropranolol, a metabolite of propranolol
1 4‐Hydroxypropranolol, a metabolite produced after oral administration of propranolol, has been shown to be a β‐adrenoceptor… 
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