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4-hydroxypropranolol

Known as: 1-(4-hydroxynaphth-1-yloxy)-3-isopropylamino-2- propanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-1-naphthalenol 
National Institutes of Health

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Broader (1)

Propranolol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Molecular modeling study of the recognition mechanism and enantioseparation of 4-hydroxypropranolol by capillary electrophoresis using carboxymethyl-β-cyclodextrin as the chiral selector.
The purpose of this paper was to study at the molecular level the enantioseparation mechanism of 4-hydroxypropranolol (4-OH-Prop… 
2009
2009
Enantioselective analysis of propranolol and 4‐hydroxypropranolol by CE with application to biotransformation studies employing endophytic fungi
A CE method is described for the enantioselective analysis of propranolol (Prop) and 4‐hydroxypropranolol (4‐OH‐Prop) in liquid… 
2000
2000
Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes.
1985
1985
Propranolol plasma levels and relief of migraine. Relationship between plasma propranolol and 4-hydroxypropranolol concentrations and clinical effects.
The relationship between propranolol and 4-hydroxypropranolol plasma concentrations and relief of migraine was assessed in 17… 
Highly Cited
1984
Highly Cited
1984
Polymorphic ability to metabolize propranolol alters 4‐hydroxypropranolol levels but not beta blockade
The ability to hydroxylate debrisoquine is known to be polymorphically distributed, with about 8% to 9% of the North American… 
1981
1981
Combined high-performance liquid chromatographic procedure for measuring 4-hydroxypropranolol and propranolol in plasma: pharmacokinetic measurements following conventional and slow-release…
An assay is described for the simultaneous determination of propranolol and its active metabolite, 4-hydroxypropranolol, in human… 
Highly Cited
1980
Highly Cited
1980
4‐Hydroxypropranolol and its glucuronide after single and long‐term doses of propranolol
The disposition of the pharmacologically active 4‐hydroxypropranolol (HO‐P), its glucuronic acid conjugate (HO‐P‐G), and… 
1979
1979
Plasma concentrations of propranolol and 4-hydroxypropranolol during chronic oral propranolol therapy.
1 The plasma levels of propranolol and 4-hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral… 
1972
1972
Rat liver microsomal metabolism of propranolol: identification of seven metabolites by gas chromatography-mass spectrometry.
Highly Cited
1972
Highly Cited
1972
Pharmacodynamics of Propranolol in Renal Failure
The pharmacodynamics of propranolol were studied in patients with renal functional impairment. 14C-labelled propranolol was given… 
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