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4-hydroxymidazolam

Known as: 4-OH-MDZ 
National Institutes of Health

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2 relations

Broader (1)

Midazolam
analogs & derivatives

Papers overview

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Review
2014
Review
2014
Phenotyping of CYP450 in human liver microsomes using the cocktail approach
The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single… 
Highly Cited
2012
Highly Cited
2012
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS.
2005
2005
A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: applications to drug metabolism.
Highly Cited
2003
Highly Cited
2003
Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma by reversed-phase liquid-chromatography with electrospray ionization mass…
Highly Cited
2001
Highly Cited
2001
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A).
AIMS The use of multiple probe substrates to evaluate the activity of drug metabolizing enzymes requires that there are no inter… 
Highly Cited
1999
Highly Cited
1999
Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro.
Fentanyl decreases clearance of midazolam administered i.v., but the mechanism remains unclear. To elucidate this mechanism, we… 
Highly Cited
1996
Highly Cited
1996
Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.
Midazolam (MDZ) is metabolized in human liver microsomes by the cytochrome P450 (CYP) 3A subfamily to 1'-hydroxy (1'-OH) and 4… 
Highly Cited
1994
Highly Cited
1994
Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.
1994
1994
Determination of midazolam and two of its metabolites in human plasma by high-performance liquid chromatography.
1989
1989
Simultaneous determination of midazolam and its three hydroxy metabolites in human plasma by electron-capture gas chromatography without derivatization.
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