4-amino-N-acetyl-N-methylaniline

The significant roles that cytochrome P450 (P450) and UDP-glucuronosyl transferase (UGT) enzymes play in drug discovery cannot be… (More)

A series of 2-amino-4-m-bromoanilino-6-benzyl pyrrolo[2,3-d]pyrimidines analogues 4-12 were synthesized and evaluated as… (More)

A series of secondary amines (4–19) containing 2-chloroquinoline as lipophilic domain have been synthesized based on the… (More)

Here, we report on the mechanism by which flavin-containing monooxygenase 1 (FMO1) mediates the formation of a reactive… (More)

Owing to the great biological and industrial importance of nitrogen-containing molecules, much research has focused on the… (More)

The electron transfer from aniline and its N-methyl as well as N-phenyl substituted derivatives (N-methylaniline, N,N… (More)

The combi-targeting concept postulates that a molecule termed a "combi-molecule" designed to interact with an oncoreceptor on its… (More)

The role of single electron transfer (SET) in P450-catalyzed N-dealkylation reactions has been studied using the probe substrates… (More)

Highly purified liver microsomal cytochrome P-450 catalyzes the hydroperoxide-dependent hydroxylation of a variety of substrates… (More)

THE use of Raney metal catalysts for the reductive methylation of amines with formaldehyde and hydrogen is well known1. We wish… (More)