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3q26.3

A chromosome band present on 3q
National Institutes of Health

Related topics

Related topics

3 relations
ChromosomesPIK3CA wt AllelePRKCI wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas
Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating… 
Highly Cited
2005
Highly Cited
2005
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.
The phosphatidylinositol 3'-kinase (PI3K) pathway is activated in many human cancers. In addition to inactivation of the PTEN… 
Highly Cited
2005
Highly Cited
2005
Genetic alteration and expression of the phosphoinositol‐3‐kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas
Glioblastomas frequently carry genetic alterations resulting in an aberrant activation of the phosphoinositol‐3‐kinase (Pi3k… 
Highly Cited
2004
Highly Cited
2004
A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3
Cornelia de Lange syndrome (CdLS) is a rare developmental malformation syndrome characterised by mental handicap, growth… 
Highly Cited
2003
Highly Cited
2003
Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl‐lnositol‐3′‐Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas
Glioblastomas frequently carry mutations in the PTEN tumor suppressor gene on 10q23.3. The tumor suppressor properties of Pten… 
2002
2002
Investigations for Fine Mapping of Amplifications in Chromosome 3q26.3–28 Frequently Occurring in Squamous Cell Carcinomas of the Head and Neck
Objective: Overrepresentations of chromosomal material on the long arm of chromosome 3 frequently occur in squamous cell… 
Highly Cited
2000
Highly Cited
2000
PIK3CA as an oncogene in cervical cancer
Amplification of chromosome arm 3q is the most consistent aberration in cervical cancer, and is implicated in the progression of… 
Review
1997
Review
1997
The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: the role of telomerase reactivation.
Highly Cited
1997
Highly Cited
1997
Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas
We used comparative genomic hybridization (CGH) to identify recurrent chromosomal imbalances in tumor DNA from 25 malignant… 
Highly Cited
1994
Highly Cited
1994
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
Phosphatidylinositol (PI) 3-kinase is a heterodimeric enzyme comprising a 110-kDa catalytic subunit and an 85-kDa regulatory… 
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