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3-methyloxindole

 
National Institutes of Health

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2 relations

Broader (2)

3-methyl-2-oxindoleIndoles

Papers overview

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2003
2003
Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver
  • G. Diaz, E. Squires
  • Xenobiotica; the fate of foreign compounds in…
  • 2003
    • Corpus ID: 20384039
1. The Phase II in vitro metabolism of 3-methylindole (3MI) metabolites was investigated in pigs to determine the possible… Expand
Highly Cited
2001
Highly Cited
2001
Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes.
  • D. L. Lanza, G. Yost
  • Drug metabolism and disposition: the biological…
  • 2001
    • Corpus ID: 14828578
3-Methylindole (3 MI) is a selective pulmonary toxicant, and cytochrome P450 (P450) bioactivation of 3 MI, through hydroxylation… Expand
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1999
1999
Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes.
A study was conducted to investigate qualitative and quantitative aspects of the phase I metabolism of 3-methylindole (3MI) by… Expand
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Highly Cited
1999
Highly Cited
1999
Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.
3-Methylindole (3MI) is a naturally occurring pulmonary toxin that requires metabolic activation. Previous studies have shown… Expand
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1998
1998
Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.
The existence of a cytochrome P450-dependent 2,3-epoxide of the potent pneumotoxin 3-methylindole was indirectly confirmed using… Expand
Highly Cited
1996
Highly Cited
1996
Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.
The toxicity of 3-methylindole (3 MI), a selective pneumotoxin, is dependent upon cytochrome P450-mediated bioactivation 3. Using… Expand
1989
1989
Isolation and identification of 3-hydroxy-3-methyloxindole, the major murine metabolite of 3-methylindole.
3-Methylindole (3MI) is pneumotoxic to ruminants and rodents subsequent to metabolic oxidative activation by cytochrome P-450… Expand
1967
1967
Inhibitory oxidation products of indole-3-acetic Acid: 3-hydroxymethyloxindole and 3-methyleneoxindole as plant metabolites.
Extracts of pea seedlings (Pisum sativum, variety Alaska) oxidize indole-3-acetic acid to a bacteriostatic compound which has… Expand
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1965
1965
INHIBITORY OXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID. MECHANISM OF ACTION AND ROUTE OF DETOXIFICATION.
The use of Escherichia coli as a model organism for studies on the biochemistry of the action of indole-3-acetic acid has… Expand
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1964
1964
INHIBITION OF CELL GROWTH BY PHOTOOXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID.
Indole-a-acetic acid is well known as an inducer as well as an inhibitor of several growth and differentiative processes in… Expand
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