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3-methyloxindole

 
National Institutes of Health

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2 relations

Broader (2)

3-methyl-2-oxindoleIndoles

Papers overview

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2007
2007
Metabolism and bioactivation of 3-methylindole by human liver microsomes.
Metabolism and bioactivation of 3-methylindole (3MI) were investigated in human liver microsomes. The metabolism of two deuterium… Expand
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2006
2006
The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes.
The accumulation of 3-methylindole (3MI) in uncastrated male pigs (boars) is a major cause of boar taint, which negatively… Expand
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2003
2003
Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver
1. The Phase II in vitro metabolism of 3-methylindole (3MI) metabolites was investigated in pigs to determine the possible… Expand
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2001
2001
Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes.
3-Methylindole (3 MI) is a selective pulmonary toxicant, and cytochrome P450 (P450) bioactivation of 3 MI, through hydroxylation… Expand
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1999
1999
Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes.
A study was conducted to investigate qualitative and quantitative aspects of the phase I metabolism of 3-methylindole (3MI) by… Expand
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Highly Cited
1999
Highly Cited
1999
Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.
3-Methylindole (3MI) is a naturally occurring pulmonary toxin that requires metabolic activation. Previous studies have shown… Expand
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1998
1998
Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.
The existence of a cytochrome P450-dependent 2,3-epoxide of the potent pneumotoxin 3-methylindole was indirectly confirmed using… Expand
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1996
1996
Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.
The toxicity of 3-methylindole (3 MI), a selective pneumotoxin, is dependent upon cytochrome P450-mediated bioactivation 3. Using… Expand
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1991
1991
Degradation of substituted indoles by an indole-degrading methanogenic consortium.
Degradation of indole by an indole-degrading methanogenic consortium enriched from sewage sludge proceeded through a two-step… Expand
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1967
1967
Inhibitory oxidation products of indole-3-acetic Acid: 3-hydroxymethyloxindole and 3-methyleneoxindole as plant metabolites.
Extracts of pea seedlings (Pisum sativum, variety Alaska) oxidize indole-3-acetic acid to a bacteriostatic compound which has… Expand
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